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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPD4
All Species:
8.79
Human Site:
S253
Identified Species:
19.33
UniProt:
Q9NXE4
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NXE4
NP_060221.2
827
93352
S253
S
V
N
A
D
P
A
S
H
E
I
W
R
S
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543560
827
93189
S253
S
V
N
A
D
P
A
S
H
E
I
W
R
S
E
Cat
Felis silvestris
Mouse
Mus musculus
Q6ZPR5
823
93257
H253
V
N
A
D
P
A
S
H
E
I
W
R
S
E
T
Rat
Rattus norvegicus
NP_001161278
823
93261
H253
V
N
A
D
P
A
S
H
E
I
W
R
S
E
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509989
509
58534
Chicken
Gallus gallus
XP_415236
827
94779
S253
S
V
N
A
D
P
A
S
Q
E
I
W
R
S
E
Frog
Xenopus laevis
Q5XHG1
824
93777
Q254
V
N
A
D
P
A
A
Q
E
I
W
R
T
E
T
Zebra Danio
Brachydanio rerio
Q6PFJ7
791
89972
A247
S
V
N
A
D
P
A
A
Q
E
I
W
R
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650124
767
86929
I233
R
Q
P
R
Y
I
K
I
P
S
S
Y
R
N
G
Honey Bee
Apis mellifera
XP_623882
744
86631
P218
S
I
L
S
P
G
S
P
T
S
T
A
T
V
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784153
874
98584
P239
G
H
A
H
Q
R
S
P
T
Q
H
Q
D
T
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
92
N.A.
89.8
90.3
N.A.
46.1
74.9
66.2
60.5
N.A.
24.2
29.5
N.A.
31
Protein Similarity:
100
N.A.
N.A.
94.5
N.A.
93.8
93.9
N.A.
51.8
83.9
77.6
71.9
N.A.
42.2
47.4
N.A.
49.2
P-Site Identity:
100
N.A.
N.A.
100
N.A.
0
0
N.A.
0
93.3
6.6
86.6
N.A.
6.6
6.6
N.A.
0
P-Site Similarity:
100
N.A.
N.A.
100
N.A.
6.6
6.6
N.A.
0
93.3
6.6
93.3
N.A.
20
26.6
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
37
37
0
28
46
10
0
0
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
28
37
0
0
0
0
0
0
0
10
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
28
37
0
0
0
28
37
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
0
0
10
0
0
0
0
0
0
0
0
10
% G
% His:
0
10
0
10
0
0
0
19
19
0
10
0
0
0
0
% H
% Ile:
0
10
0
0
0
10
0
10
0
28
37
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
28
37
0
0
0
0
0
0
0
0
0
0
10
0
% N
% Pro:
0
0
10
0
37
37
0
19
10
0
0
0
0
0
10
% P
% Gln:
0
10
0
0
10
0
0
10
19
10
0
10
0
0
0
% Q
% Arg:
10
0
0
10
0
10
0
0
0
0
0
28
46
0
0
% R
% Ser:
46
0
0
10
0
0
37
28
0
19
10
0
19
37
0
% S
% Thr:
0
0
0
0
0
0
0
0
19
0
10
0
19
10
37
% T
% Val:
28
37
0
0
0
0
0
0
0
0
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
28
37
0
0
0
% W
% Tyr:
0
0
0
0
10
0
0
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _