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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPD4
All Species:
16.06
Human Site:
S753
Identified Species:
35.33
UniProt:
Q9NXE4
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NXE4
NP_060221.2
827
93352
S753
L
A
S
R
H
L
L
S
P
V
G
R
R
Q
V
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543560
827
93189
S753
V
T
G
R
H
L
L
S
P
V
A
R
E
S
A
Cat
Felis silvestris
Mouse
Mus musculus
Q6ZPR5
823
93257
S749
L
S
N
R
H
L
L
S
P
V
G
R
R
Q
V
Rat
Rattus norvegicus
NP_001161278
823
93261
S749
L
S
N
R
H
L
L
S
P
V
G
R
R
Q
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509989
509
58534
S436
G
E
E
R
T
R
I
S
P
E
G
R
H
R
T
Chicken
Gallus gallus
XP_415236
827
94779
S754
L
V
H
K
I
R
Y
S
P
V
L
K
D
R
T
Frog
Xenopus laevis
Q5XHG1
824
93777
K750
S
S
S
R
K
C
K
K
S
P
I
T
S
V
S
Zebra Danio
Brachydanio rerio
Q6PFJ7
791
89972
E715
S
S
S
S
A
V
V
E
Q
R
R
K
S
P
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650124
767
86929
A692
V
A
R
Q
L
L
Y
A
P
M
T
E
Q
W
F
Honey Bee
Apis mellifera
XP_623882
744
86631
P671
C
G
Y
E
E
R
I
P
P
R
L
S
L
R
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784153
874
98584
D783
S
P
P
S
H
A
L
D
P
A
G
R
A
P
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
92
N.A.
89.8
90.3
N.A.
46.1
74.9
66.2
60.5
N.A.
24.2
29.5
N.A.
31
Protein Similarity:
100
N.A.
N.A.
94.5
N.A.
93.8
93.9
N.A.
51.8
83.9
77.6
71.9
N.A.
42.2
47.4
N.A.
49.2
P-Site Identity:
100
N.A.
N.A.
53.3
N.A.
86.6
86.6
N.A.
33.3
26.6
13.3
13.3
N.A.
20
6.6
N.A.
33.3
P-Site Similarity:
100
N.A.
N.A.
60
N.A.
100
100
N.A.
46.6
46.6
20
40
N.A.
53.3
20
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
19
0
0
10
10
0
10
0
10
10
0
10
0
10
% A
% Cys:
10
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
0
0
0
0
10
0
0
% D
% Glu:
0
10
10
10
10
0
0
10
0
10
0
10
10
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% F
% Gly:
10
10
10
0
0
0
0
0
0
0
46
0
0
0
0
% G
% His:
0
0
10
0
46
0
0
0
0
0
0
0
10
0
0
% H
% Ile:
0
0
0
0
10
0
19
0
0
0
10
0
0
0
0
% I
% Lys:
0
0
0
10
10
0
10
10
0
0
0
19
0
0
0
% K
% Leu:
37
0
0
0
10
46
46
0
0
0
19
0
10
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% M
% Asn:
0
0
19
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
10
10
0
0
0
0
10
82
10
0
0
0
19
10
% P
% Gln:
0
0
0
10
0
0
0
0
10
0
0
0
10
28
0
% Q
% Arg:
0
0
10
55
0
28
0
0
0
19
10
55
28
28
0
% R
% Ser:
28
37
28
19
0
0
0
55
10
0
0
10
19
10
19
% S
% Thr:
0
10
0
0
10
0
0
0
0
0
10
10
0
0
19
% T
% Val:
19
10
0
0
0
10
10
0
0
46
0
0
0
10
37
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% W
% Tyr:
0
0
10
0
0
0
19
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _