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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CCDC49 All Species: 16.97
Human Site: S281 Identified Species: 28.72
UniProt: Q9NXE8 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NXE8 NP_060218.1 425 49647 S281 K S T R E A G S R D R R S R S
Chimpanzee Pan troglodytes XP_511442 425 49656 S281 K S T R E A G S R D R R S R S
Rhesus Macaque Macaca mulatta XP_001084106 361 42039 S240 R P S K P H N S K V N R R E T
Dog Lupus familis XP_537657 420 49023 S281 K S T R E A G S R D P G R R S
Cat Felis silvestris
Mouse Mus musculus Q9DBF7 416 48793 R281 R P R D R R S R S P S R R S R
Rat Rattus norvegicus NP_001101765 415 48669 S281 S R D R R S R S P G R K S L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509896 413 46346 G291 R T D G R A D G L G R G G G P
Chicken Gallus gallus Q5ZI03 460 53359 H324 Y E D L S S S H G N K D K D R
Frog Xenopus laevis NP_001086504 387 45480 S256 K D R A R A H S Q S P H R D S
Zebra Danio Brachydanio rerio NP_998627 393 46591 S270 A D R D N H S S R E S E R K A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_608705 521 61859 K374 T R S P E D R K A R R Q S K D
Honey Bee Apis mellifera XP_624464 265 31449 E153 L Y A I K K K E M E T R N Q L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001201496 510 61353 K306 D R R R D S R K D E K K M R Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SI59 444 51384 S281 R D R D D D R S R R H R F P Q
Conservation
Percent
Protein Identity: 100 99.7 83.5 90.3 N.A. 88.9 88.9 N.A. 68.4 20 58.8 54.1 N.A. 33.4 28.4 N.A. 30
Protein Similarity: 100 100 84.2 94.1 N.A. 92.7 93.1 N.A. 77.1 34.3 73.6 70.1 N.A. 53.5 46.1 N.A. 50.7
P-Site Identity: 100 100 13.3 80 N.A. 6.6 33.3 N.A. 13.3 0 26.6 13.3 N.A. 20 6.6 N.A. 13.3
P-Site Similarity: 100 100 46.6 80 N.A. 13.3 46.6 N.A. 26.6 20 33.3 33.3 N.A. 40 33.3 N.A. 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 29
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 48.2
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 20
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 8 8 0 36 0 0 8 0 0 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 22 22 22 15 15 8 0 8 22 0 8 0 15 8 % D
% Glu: 0 8 0 0 29 0 0 8 0 22 0 8 0 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % F
% Gly: 0 0 0 8 0 0 22 8 8 15 0 15 8 8 0 % G
% His: 0 0 0 0 0 15 8 8 0 0 8 8 0 0 0 % H
% Ile: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 29 0 0 8 8 8 8 15 8 0 15 15 8 15 0 % K
% Leu: 8 0 0 8 0 0 0 0 8 0 0 0 0 8 8 % L
% Met: 0 0 0 0 0 0 0 0 8 0 0 0 8 0 0 % M
% Asn: 0 0 0 0 8 0 8 0 0 8 8 0 8 0 0 % N
% Pro: 0 15 0 8 8 0 0 0 8 8 15 0 0 8 8 % P
% Gln: 0 0 0 0 0 0 0 0 8 0 0 8 0 8 15 % Q
% Arg: 29 22 36 36 29 8 29 8 36 15 36 43 36 29 15 % R
% Ser: 8 22 15 0 8 22 22 58 8 8 15 0 29 8 36 % S
% Thr: 8 8 22 0 0 0 0 0 0 0 8 0 0 0 8 % T
% Val: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _