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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
KLHL28
All Species:
17.88
Human Site:
T249
Identified Species:
32.78
UniProt:
Q9NXS3
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NXS3
NP_060128.2
571
64192
T249
H
L
I
R
D
D
R
T
C
K
H
L
L
N
E
Chimpanzee
Pan troglodytes
XP_001149345
684
76181
E357
P
L
I
K
S
D
E
E
C
R
D
L
V
D
E
Rhesus Macaque
Macaca mulatta
XP_001095031
571
64184
T249
H
L
I
R
D
D
R
T
C
K
H
L
L
N
E
Dog
Lupus familis
XP_547790
571
64226
T249
H
L
I
R
D
D
R
T
C
K
H
L
L
N
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9CR40
571
64107
T249
H
L
I
R
D
D
R
T
C
K
H
L
L
N
E
Rat
Rattus norvegicus
Q8K430
640
69714
D304
S
L
V
R
H
H
P
D
C
K
D
L
L
I
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513616
571
64248
T249
H
L
I
R
D
D
H
T
C
K
H
L
L
N
E
Chicken
Gallus gallus
Q5ZI33
586
66177
E258
P
L
I
Q
D
N
P
E
C
L
K
M
V
I
S
Frog
Xenopus laevis
Q6NRH0
564
63190
Q243
P
L
I
R
C
S
L
Q
C
R
D
L
V
D
E
Zebra Danio
Brachydanio rerio
Q5U374
564
62914
P243
P
L
I
R
C
S
L
P
C
R
D
L
V
D
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUU5
623
68905
A286
L
L
V
R
S
D
E
A
C
R
D
L
V
D
E
Honey Bee
Apis mellifera
XP_397065
620
68991
A293
L
L
V
R
S
D
D
A
C
R
D
L
V
D
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780225
597
66997
L273
P
F
I
K
E
N
D
L
C
Q
E
Q
V
N
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
36.9
99.4
99.1
N.A.
97
38.4
N.A.
93.1
32.7
38.7
38.3
N.A.
40.1
40
N.A.
46.2
Protein Similarity:
100
53
99.4
99.6
N.A.
99.1
53.4
N.A.
96.6
50.5
56.7
57
N.A.
56.1
56.2
N.A.
65.1
P-Site Identity:
100
40
100
100
N.A.
100
46.6
N.A.
93.3
26.6
40
40
N.A.
40
40
N.A.
20
P-Site Similarity:
100
66.6
100
100
N.A.
100
53.3
N.A.
93.3
53.3
60
60
N.A.
66.6
66.6
N.A.
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
16
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
16
0
0
0
100
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
47
62
16
8
0
0
47
0
0
39
0
% D
% Glu:
0
0
0
0
8
0
16
16
0
0
8
0
0
0
85
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
39
0
0
0
8
8
8
0
0
0
39
0
0
0
0
% H
% Ile:
0
0
77
0
0
0
0
0
0
0
0
0
0
16
0
% I
% Lys:
0
0
0
16
0
0
0
0
0
47
8
0
0
0
8
% K
% Leu:
16
93
0
0
0
0
16
8
0
8
0
85
47
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
0
0
0
16
0
0
0
0
0
0
0
47
0
% N
% Pro:
39
0
0
0
0
0
16
8
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
8
0
0
0
8
0
8
0
8
0
0
0
% Q
% Arg:
0
0
0
77
0
0
31
0
0
39
0
0
0
0
0
% R
% Ser:
8
0
0
0
24
16
0
0
0
0
0
0
0
0
8
% S
% Thr:
0
0
0
0
0
0
0
39
0
0
0
0
0
0
0
% T
% Val:
0
0
24
0
0
0
0
0
0
0
0
0
54
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _