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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMPD3 All Species: 10.3
Human Site: S236 Identified Species: 22.67
UniProt: Q9NY59 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NY59 NP_061137.1 655 71081 S236 A S G D P V D S S S P E D A C
Chimpanzee Pan troglodytes XP_001167790 655 71064 S236 A S G D P V D S S S P E D A C
Rhesus Macaque Macaca mulatta XP_001091683 730 78991 G236 A S G D P V D G S S P E D A C
Dog Lupus familis XP_546863 658 71463 G236 A S G D P A E G V G L E D A C
Cat Felis silvestris
Mouse Mus musculus Q9JJY3 655 71178 G235 A S G E Q A D G S L E D S C I
Rat Rattus norvegicus O35049 655 71254 G235 A S G E Q A D G S L E D S C I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521026 485 53083 L130 F L T A N L C L F S D G L A R
Chicken Gallus gallus XP_429344 662 73371 N236 K A G S G E L N E G E E N T C
Frog Xenopus laevis NP_001089663 659 73316 T257 D S G H I S D T E T D A I S G
Zebra Danio Brachydanio rerio NP_001116222 684 75995 S239 S S D C P I H S T G V Q N S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782298 603 68480 T226 E S A G S T S T V R L Q T S Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 86.3 89 N.A. 91.3 90.9 N.A. 30.9 72.8 69.5 56.7 N.A. N.A. N.A. N.A. 27.3
Protein Similarity: 100 99.6 87.5 92.7 N.A. 94.5 94 N.A. 42.5 81.4 81 71.3 N.A. N.A. N.A. N.A. 43.8
P-Site Identity: 100 100 93.3 60 N.A. 33.3 33.3 N.A. 13.3 20 20 20 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 93.3 66.6 N.A. 46.6 46.6 N.A. 20 40 40 60 N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 55 10 10 10 0 28 0 0 0 0 0 10 0 46 0 % A
% Cys: 0 0 0 10 0 0 10 0 0 0 0 0 0 19 46 % C
% Asp: 10 0 10 37 0 0 55 0 0 0 19 19 37 0 0 % D
% Glu: 10 0 0 19 0 10 10 0 19 0 28 46 0 0 0 % E
% Phe: 10 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % F
% Gly: 0 0 73 10 10 0 0 37 0 28 0 10 0 0 10 % G
% His: 0 0 0 10 0 0 10 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 10 10 0 0 0 0 0 0 10 0 19 % I
% Lys: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 10 0 0 0 10 10 10 0 19 19 0 10 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 10 0 0 10 0 0 0 0 19 0 0 % N
% Pro: 0 0 0 0 46 0 0 0 0 0 28 0 0 0 0 % P
% Gln: 0 0 0 0 19 0 0 0 0 0 0 19 0 0 10 % Q
% Arg: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 10 % R
% Ser: 10 82 0 10 10 10 10 28 46 37 0 0 19 28 10 % S
% Thr: 0 0 10 0 0 10 0 19 10 10 0 0 10 10 0 % T
% Val: 0 0 0 0 0 28 0 0 19 0 10 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _