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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPD3
All Species:
11.52
Human Site:
S238
Identified Species:
25.33
UniProt:
Q9NY59
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NY59
NP_061137.1
655
71081
S238
G
D
P
V
D
S
S
S
P
E
D
A
C
I
V
Chimpanzee
Pan troglodytes
XP_001167790
655
71064
S238
G
D
P
V
D
S
S
S
P
E
D
A
C
I
V
Rhesus Macaque
Macaca mulatta
XP_001091683
730
78991
S238
G
D
P
V
D
G
S
S
P
E
D
A
C
I
V
Dog
Lupus familis
XP_546863
658
71463
G238
G
D
P
A
E
G
V
G
L
E
D
A
C
I
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9JJY3
655
71178
L237
G
E
Q
A
D
G
S
L
E
D
S
C
I
V
R
Rat
Rattus norvegicus
O35049
655
71254
L237
G
E
Q
A
D
G
S
L
E
D
S
C
I
V
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521026
485
53083
S132
T
A
N
L
C
L
F
S
D
G
L
A
R
F
S
Chicken
Gallus gallus
XP_429344
662
73371
G238
G
S
G
E
L
N
E
G
E
E
N
T
C
I
V
Frog
Xenopus laevis
NP_001089663
659
73316
T259
G
H
I
S
D
T
E
T
D
A
I
S
G
H
V
Zebra Danio
Brachydanio rerio
NP_001116222
684
75995
G241
D
C
P
I
H
S
T
G
V
Q
N
S
S
E
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782298
603
68480
R228
A
G
S
T
S
T
V
R
L
Q
T
S
Q
S
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
86.3
89
N.A.
91.3
90.9
N.A.
30.9
72.8
69.5
56.7
N.A.
N.A.
N.A.
N.A.
27.3
Protein Similarity:
100
99.6
87.5
92.7
N.A.
94.5
94
N.A.
42.5
81.4
81
71.3
N.A.
N.A.
N.A.
N.A.
43.8
P-Site Identity:
100
100
93.3
60
N.A.
20
20
N.A.
13.3
33.3
20
13.3
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
93.3
66.6
N.A.
40
40
N.A.
20
46.6
40
46.6
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
0
28
0
0
0
0
0
10
0
46
0
0
0
% A
% Cys:
0
10
0
0
10
0
0
0
0
0
0
19
46
0
10
% C
% Asp:
10
37
0
0
55
0
0
0
19
19
37
0
0
0
0
% D
% Glu:
0
19
0
10
10
0
19
0
28
46
0
0
0
10
0
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
0
0
0
10
0
% F
% Gly:
73
10
10
0
0
37
0
28
0
10
0
0
10
0
0
% G
% His:
0
10
0
0
10
0
0
0
0
0
0
0
0
10
0
% H
% Ile:
0
0
10
10
0
0
0
0
0
0
10
0
19
46
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
10
10
10
0
19
19
0
10
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
10
0
0
0
0
19
0
0
0
0
% N
% Pro:
0
0
46
0
0
0
0
0
28
0
0
0
0
0
0
% P
% Gln:
0
0
19
0
0
0
0
0
0
19
0
0
10
0
10
% Q
% Arg:
0
0
0
0
0
0
0
10
0
0
0
0
10
0
19
% R
% Ser:
0
10
10
10
10
28
46
37
0
0
19
28
10
10
10
% S
% Thr:
10
0
0
10
0
19
10
10
0
0
10
10
0
0
0
% T
% Val:
0
0
0
28
0
0
19
0
10
0
0
0
0
19
55
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _