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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SMPD3 All Species: 31.52
Human Site: S296 Identified Species: 69.33
UniProt: Q9NY59 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NY59 NP_061137.1 655 71081 S296 S G S L G S P S A S R E S L V
Chimpanzee Pan troglodytes XP_001167790 655 71064 S296 S G S L G S P S A S R E S L V
Rhesus Macaque Macaca mulatta XP_001091683 730 78991 S296 S G S L G S P S A S R E S L V
Dog Lupus familis XP_546863 658 71463 S296 S G S L G S P S A S R E S L V
Cat Felis silvestris
Mouse Mus musculus Q9JJY3 655 71178 S294 S G S L G S P S A S R E S L V
Rat Rattus norvegicus O35049 655 71254 S294 S G S L G S P S A S R E S L V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521026 485 53083 K164 K W S R G G G K G S A Y G T T
Chicken Gallus gallus XP_429344 662 73371 S303 S G S L D S Y S A S R E S L V
Frog Xenopus laevis NP_001089663 659 73316 S298 A D G G S L D S Y T A S R E S
Zebra Danio Brachydanio rerio NP_001116222 684 75995 T324 T G S L D S R T A S R E S L V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782298 603 68480 F261 I T R C P M S F C S Q S S I R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 86.3 89 N.A. 91.3 90.9 N.A. 30.9 72.8 69.5 56.7 N.A. N.A. N.A. N.A. 27.3
Protein Similarity: 100 99.6 87.5 92.7 N.A. 94.5 94 N.A. 42.5 81.4 81 71.3 N.A. N.A. N.A. N.A. 43.8
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 20 86.6 6.6 73.3 N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 20 86.6 20 86.6 N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 0 0 0 0 0 73 0 19 0 0 0 0 % A
% Cys: 0 0 0 10 0 0 0 0 10 0 0 0 0 0 0 % C
% Asp: 0 10 0 0 19 0 10 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 73 0 10 0 % E
% Phe: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % F
% Gly: 0 73 10 10 64 10 10 0 10 0 0 0 10 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % I
% Lys: 10 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 73 0 10 0 0 0 0 0 0 0 73 0 % L
% Met: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 10 0 55 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % Q
% Arg: 0 0 10 10 0 0 10 0 0 0 73 0 10 0 10 % R
% Ser: 64 0 82 0 10 73 10 73 0 91 0 19 82 0 10 % S
% Thr: 10 10 0 0 0 0 0 10 0 10 0 0 0 10 10 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 73 % V
% Trp: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 10 0 10 0 0 10 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _