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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPD3
All Species:
31.52
Human Site:
S296
Identified Species:
69.33
UniProt:
Q9NY59
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NY59
NP_061137.1
655
71081
S296
S
G
S
L
G
S
P
S
A
S
R
E
S
L
V
Chimpanzee
Pan troglodytes
XP_001167790
655
71064
S296
S
G
S
L
G
S
P
S
A
S
R
E
S
L
V
Rhesus Macaque
Macaca mulatta
XP_001091683
730
78991
S296
S
G
S
L
G
S
P
S
A
S
R
E
S
L
V
Dog
Lupus familis
XP_546863
658
71463
S296
S
G
S
L
G
S
P
S
A
S
R
E
S
L
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9JJY3
655
71178
S294
S
G
S
L
G
S
P
S
A
S
R
E
S
L
V
Rat
Rattus norvegicus
O35049
655
71254
S294
S
G
S
L
G
S
P
S
A
S
R
E
S
L
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521026
485
53083
K164
K
W
S
R
G
G
G
K
G
S
A
Y
G
T
T
Chicken
Gallus gallus
XP_429344
662
73371
S303
S
G
S
L
D
S
Y
S
A
S
R
E
S
L
V
Frog
Xenopus laevis
NP_001089663
659
73316
S298
A
D
G
G
S
L
D
S
Y
T
A
S
R
E
S
Zebra Danio
Brachydanio rerio
NP_001116222
684
75995
T324
T
G
S
L
D
S
R
T
A
S
R
E
S
L
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782298
603
68480
F261
I
T
R
C
P
M
S
F
C
S
Q
S
S
I
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
86.3
89
N.A.
91.3
90.9
N.A.
30.9
72.8
69.5
56.7
N.A.
N.A.
N.A.
N.A.
27.3
Protein Similarity:
100
99.6
87.5
92.7
N.A.
94.5
94
N.A.
42.5
81.4
81
71.3
N.A.
N.A.
N.A.
N.A.
43.8
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
20
86.6
6.6
73.3
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
86.6
20
86.6
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
0
0
0
73
0
19
0
0
0
0
% A
% Cys:
0
0
0
10
0
0
0
0
10
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
19
0
10
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
73
0
10
0
% E
% Phe:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% F
% Gly:
0
73
10
10
64
10
10
0
10
0
0
0
10
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% I
% Lys:
10
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
73
0
10
0
0
0
0
0
0
0
73
0
% L
% Met:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
10
0
55
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% Q
% Arg:
0
0
10
10
0
0
10
0
0
0
73
0
10
0
10
% R
% Ser:
64
0
82
0
10
73
10
73
0
91
0
19
82
0
10
% S
% Thr:
10
10
0
0
0
0
0
10
0
10
0
0
0
10
10
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
73
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
0
10
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _