KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPHK1
All Species:
12.42
Human Site:
S225
Identified Species:
24.85
UniProt:
Q9NYA1
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NYA1
NP_001136073.1
384
42518
S225
V
G
S
K
T
P
A
S
P
V
V
V
Q
Q
G
Chimpanzee
Pan troglodytes
XP_001171292
616
65423
A355
E
P
A
S
P
T
P
A
H
S
L
P
R
A
K
Rhesus Macaque
Macaca mulatta
XP_001099066
513
55416
S311
A
G
S
K
T
P
V
S
P
V
V
V
Q
Q
G
Dog
Lupus familis
XP_540448
477
51774
S315
V
V
S
Q
V
P
T
S
P
A
V
D
R
Q
N
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI15
382
42425
S225
V
A
S
K
R
P
A
S
T
L
V
Q
K
G
P
Rat
Rattus norvegicus
Q91V26
383
42400
S225
A
A
S
K
I
P
A
S
S
L
A
Q
K
G
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508019
326
34847
A194
P
L
E
Q
P
V
P
A
H
W
T
V
V
P
E
Chicken
Gallus gallus
XP_425374
361
38864
R206
E
P
G
T
P
R
D
R
K
A
P
A
R
R
A
Frog
Xenopus laevis
NP_001088560
509
55981
S354
S
V
D
T
A
P
E
S
D
S
H
R
R
T
L
Zebra Danio
Brachydanio rerio
XP_001922084
310
33789
L184
E
N
L
L
N
D
H
L
M
A
P
F
G
Q
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002317243
494
54399
F325
P
T
R
Y
N
G
E
F
T
S
T
Q
S
S
I
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_001031689
485
53680
K329
R
A
S
C
S
I
D
K
E
P
S
G
S
D
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
29
64.3
72.5
N.A.
80.7
78.1
N.A.
51.5
50.2
40
44.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
40.2
67.2
75.6
N.A.
89.3
89
N.A.
61.2
63.5
51.6
58.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
0
86.6
46.6
N.A.
46.6
33.3
N.A.
6.6
0
13.3
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
26.6
86.6
60
N.A.
60
46.6
N.A.
20
13.3
20
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
23.4
N.A.
N.A.
23.5
N.A.
N.A.
Protein Similarity:
39
N.A.
N.A.
36.4
N.A.
N.A.
P-Site Identity:
0
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
0
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
25
9
0
9
0
25
17
0
25
9
9
0
9
9
% A
% Cys:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
0
0
9
17
0
9
0
0
9
0
9
0
% D
% Glu:
25
0
9
0
0
0
17
0
9
0
0
0
0
0
9
% E
% Phe:
0
0
0
0
0
0
0
9
0
0
0
9
0
0
0
% F
% Gly:
0
17
9
0
0
9
0
0
0
0
0
9
9
17
17
% G
% His:
0
0
0
0
0
0
9
0
17
0
9
0
0
0
0
% H
% Ile:
0
0
0
0
9
9
0
0
0
0
0
0
0
0
9
% I
% Lys:
0
0
0
34
0
0
0
9
9
0
0
0
17
0
17
% K
% Leu:
0
9
9
9
0
0
0
9
0
17
9
0
0
0
9
% L
% Met:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% M
% Asn:
0
9
0
0
17
0
0
0
0
0
0
0
0
0
9
% N
% Pro:
17
17
0
0
25
50
17
0
25
9
17
9
0
9
25
% P
% Gln:
0
0
0
17
0
0
0
0
0
0
0
25
17
34
0
% Q
% Arg:
9
0
9
0
9
9
0
9
0
0
0
9
34
9
0
% R
% Ser:
9
0
50
9
9
0
0
50
9
25
9
0
17
9
0
% S
% Thr:
0
9
0
17
17
9
9
0
17
0
17
0
0
9
0
% T
% Val:
25
17
0
0
9
9
9
0
0
17
34
25
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _