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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPHK1
All Species:
26.67
Human Site:
T193
Identified Species:
53.33
UniProt:
Q9NYA1
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NYA1
NP_001136073.1
384
42518
T193
R
L
G
E
M
R
F
T
L
G
T
F
L
R
L
Chimpanzee
Pan troglodytes
XP_001171292
616
65423
T323
A
L
G
S
A
R
F
T
L
G
T
V
L
G
L
Rhesus Macaque
Macaca mulatta
XP_001099066
513
55416
T279
R
L
G
E
M
R
F
T
L
G
T
F
L
R
L
Dog
Lupus familis
XP_540448
477
51774
T283
R
L
G
E
M
R
F
T
L
G
T
F
L
R
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI15
382
42425
T193
R
L
G
E
I
R
F
T
V
G
T
F
F
R
L
Rat
Rattus norvegicus
Q91V26
383
42400
T193
S
L
G
E
I
R
F
T
V
G
T
F
F
R
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508019
326
34847
D162
P
P
A
P
A
S
S
D
P
S
P
P
V
P
G
Chicken
Gallus gallus
XP_425374
361
38864
T174
R
L
G
N
A
R
F
T
L
G
T
L
Q
C
L
Frog
Xenopus laevis
NP_001088560
509
55981
S322
F
M
G
S
A
R
F
S
F
G
T
F
V
R
L
Zebra Danio
Brachydanio rerio
XP_001922084
310
33789
A152
L
G
T
L
V
R
L
A
S
L
R
I
Y
Q
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002317243
494
54399
R293
L
D
F
Y
G
L
Q
R
M
L
C
L
R
Q
Y
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_001031689
485
53680
R297
F
D
I
Y
G
L
Q
R
I
I
C
L
R
Q
Y
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
29
64.3
72.5
N.A.
80.7
78.1
N.A.
51.5
50.2
40
44.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
40.2
67.2
75.6
N.A.
89.3
89
N.A.
61.2
63.5
51.6
58.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
66.6
100
100
N.A.
80
73.3
N.A.
0
66.6
53.3
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
66.6
100
100
N.A.
93.3
86.6
N.A.
6.6
66.6
73.3
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
23.4
N.A.
N.A.
23.5
N.A.
N.A.
Protein Similarity:
39
N.A.
N.A.
36.4
N.A.
N.A.
P-Site Identity:
0
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
9
0
34
0
0
9
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
17
0
0
9
0
% C
% Asp:
0
17
0
0
0
0
0
9
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
42
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
17
0
9
0
0
0
67
0
9
0
0
50
17
0
0
% F
% Gly:
0
9
67
0
17
0
0
0
0
67
0
0
0
9
17
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
9
0
17
0
0
0
9
9
0
9
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
17
59
0
9
0
17
9
0
42
17
0
25
34
0
67
% L
% Met:
0
9
0
0
25
0
0
0
9
0
0
0
0
0
0
% M
% Asn:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
9
9
0
9
0
0
0
0
9
0
9
9
0
9
0
% P
% Gln:
0
0
0
0
0
0
17
0
0
0
0
0
9
25
0
% Q
% Arg:
42
0
0
0
0
75
0
17
0
0
9
0
17
50
0
% R
% Ser:
9
0
0
17
0
9
9
9
9
9
0
0
0
0
0
% S
% Thr:
0
0
9
0
0
0
0
59
0
0
67
0
0
0
0
% T
% Val:
0
0
0
0
9
0
0
0
17
0
0
9
17
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
17
0
0
0
0
0
0
0
0
9
0
17
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _