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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPHK1
All Species:
13.64
Human Site:
Y126
Identified Species:
27.27
UniProt:
Q9NYA1
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NYA1
NP_001136073.1
384
42518
Y126
S
L
N
H
Y
A
G
Y
E
Q
V
T
N
E
D
Chimpanzee
Pan troglodytes
XP_001171292
616
65423
F256
A
V
N
Q
H
G
G
F
E
P
A
L
G
L
D
Rhesus Macaque
Macaca mulatta
XP_001099066
513
55416
Y212
S
L
N
H
Y
A
G
Y
E
Q
V
T
N
E
D
Dog
Lupus familis
XP_540448
477
51774
Y216
S
L
N
H
Y
A
G
Y
E
Q
V
T
N
E
D
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI15
382
42425
Y126
S
V
N
H
Y
A
G
Y
E
Q
V
T
N
E
D
Rat
Rattus norvegicus
Q91V26
383
42400
H126
S
L
N
Y
Y
A
G
H
E
Q
V
T
N
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508019
326
34847
G95
L
S
L
Q
T
A
S
G
R
R
L
F
S
L
L
Chicken
Gallus gallus
XP_425374
361
38864
N107
S
I
N
Y
Y
A
G
N
D
H
V
A
K
K
K
Frog
Xenopus laevis
NP_001088560
509
55981
H255
S
I
S
Y
Y
S
G
H
K
Q
A
V
G
N
K
Zebra Danio
Brachydanio rerio
XP_001922084
310
33789
L85
S
P
V
W
G
E
D
L
L
T
S
C
G
F
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002317243
494
54399
E226
S
T
L
D
S
A
G
E
P
C
T
A
S
N
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_001031689
485
53680
L230
S
L
L
E
P
V
G
L
P
C
S
A
T
S
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
29
64.3
72.5
N.A.
80.7
78.1
N.A.
51.5
50.2
40
44.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
40.2
67.2
75.6
N.A.
89.3
89
N.A.
61.2
63.5
51.6
58.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
26.6
100
100
N.A.
93.3
86.6
N.A.
6.6
40
26.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
53.3
100
100
N.A.
100
100
N.A.
26.6
66.6
66.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
23.4
N.A.
N.A.
23.5
N.A.
N.A.
Protein Similarity:
39
N.A.
N.A.
36.4
N.A.
N.A.
P-Site Identity:
20
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
67
0
0
0
0
17
25
0
0
17
% A
% Cys:
0
0
0
0
0
0
0
0
0
17
0
9
0
0
0
% C
% Asp:
0
0
0
9
0
0
9
0
9
0
0
0
0
0
50
% D
% Glu:
0
0
0
9
0
9
0
9
50
0
0
0
0
42
0
% E
% Phe:
0
0
0
0
0
0
0
9
0
0
0
9
0
9
0
% F
% Gly:
0
0
0
0
9
9
84
9
0
0
0
0
25
0
0
% G
% His:
0
0
0
34
9
0
0
17
0
9
0
0
0
0
0
% H
% Ile:
0
17
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
9
0
0
0
9
9
17
% K
% Leu:
9
42
25
0
0
0
0
17
9
0
9
9
0
17
17
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
59
0
0
0
0
9
0
0
0
0
42
17
0
% N
% Pro:
0
9
0
0
9
0
0
0
17
9
0
0
0
0
0
% P
% Gln:
0
0
0
17
0
0
0
0
0
50
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
9
9
0
0
0
0
0
% R
% Ser:
84
9
9
0
9
9
9
0
0
0
17
0
17
9
0
% S
% Thr:
0
9
0
0
9
0
0
0
0
9
9
42
9
0
0
% T
% Val:
0
17
9
0
0
9
0
0
0
0
50
9
0
0
0
% V
% Trp:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
25
59
0
0
34
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _