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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPHK1
All Species:
9.39
Human Site:
Y314
Identified Species:
18.79
UniProt:
Q9NYA1
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NYA1
NP_001136073.1
384
42518
Y314
E
K
G
R
H
M
E
Y
E
C
P
Y
L
V
Y
Chimpanzee
Pan troglodytes
XP_001171292
616
65423
L557
E
R
G
S
H
F
S
L
G
C
P
Q
L
G
Y
Rhesus Macaque
Macaca mulatta
XP_001099066
513
55416
Y400
E
K
G
R
H
M
E
Y
E
C
P
Y
L
V
Y
Dog
Lupus familis
XP_540448
477
51774
Y407
E
K
G
R
H
M
E
Y
D
C
P
Y
L
V
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI15
382
42425
L313
Q
K
G
K
H
M
E
L
D
C
P
Y
L
V
H
Rat
Rattus norvegicus
Q91V26
383
42400
L313
Q
K
G
K
H
M
D
L
D
C
P
Y
L
V
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508019
326
34847
H268
Q
G
C
T
H
L
V
H
V
P
V
S
A
F
R
Chicken
Gallus gallus
XP_425374
361
38864
H307
L
A
M
G
R
G
T
H
L
D
L
N
C
P
H
Frog
Xenopus laevis
NP_001088560
509
55981
E455
E
K
G
T
H
L
H
E
S
I
P
H
I
I
N
Zebra Danio
Brachydanio rerio
XP_001922084
310
33789
T257
F
R
A
M
Q
S
G
T
H
L
D
C
G
C
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002317243
494
54399
V420
N
L
S
D
G
G
H
V
K
S
P
H
V
M
Y
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_001031689
485
53680
V413
K
L
S
D
G
T
H
V
Q
S
P
Y
A
S
Y
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
29
64.3
72.5
N.A.
80.7
78.1
N.A.
51.5
50.2
40
44.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
40.2
67.2
75.6
N.A.
89.3
89
N.A.
61.2
63.5
51.6
58.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
46.6
100
93.3
N.A.
66.6
60
N.A.
6.6
0
33.3
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
53.3
100
100
N.A.
93.3
93.3
N.A.
26.6
13.3
60
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
23.4
N.A.
N.A.
23.5
N.A.
N.A.
Protein Similarity:
39
N.A.
N.A.
36.4
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
40
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
9
0
0
0
0
0
0
0
0
0
17
0
9
% A
% Cys:
0
0
9
0
0
0
0
0
0
50
0
9
9
9
0
% C
% Asp:
0
0
0
17
0
0
9
0
25
9
9
0
0
0
0
% D
% Glu:
42
0
0
0
0
0
34
9
17
0
0
0
0
0
0
% E
% Phe:
9
0
0
0
0
9
0
0
0
0
0
0
0
9
0
% F
% Gly:
0
9
59
9
17
17
9
0
9
0
0
0
9
9
0
% G
% His:
0
0
0
0
67
0
25
17
9
0
0
17
0
0
25
% H
% Ile:
0
0
0
0
0
0
0
0
0
9
0
0
9
9
0
% I
% Lys:
9
50
0
17
0
0
0
0
9
0
0
0
0
0
0
% K
% Leu:
9
17
0
0
0
17
0
25
9
9
9
0
50
0
0
% L
% Met:
0
0
9
9
0
42
0
0
0
0
0
0
0
9
0
% M
% Asn:
9
0
0
0
0
0
0
0
0
0
0
9
0
0
9
% N
% Pro:
0
0
0
0
0
0
0
0
0
9
75
0
0
9
0
% P
% Gln:
25
0
0
0
9
0
0
0
9
0
0
9
0
0
0
% Q
% Arg:
0
17
0
25
9
0
0
0
0
0
0
0
0
0
9
% R
% Ser:
0
0
17
9
0
9
9
0
9
17
0
9
0
9
0
% S
% Thr:
0
0
0
17
0
9
9
9
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
9
17
9
0
9
0
9
42
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
25
0
0
0
50
0
0
50
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _