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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CYP39A1 All Species: 23.64
Human Site: T74 Identified Species: 47.27
UniProt: Q9NYL5 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NYL5 NP_057677.2 469 54116 T74 F A M G N R M T F V T E E E G
Chimpanzee Pan troglodytes XP_518518 469 54055 T74 F A M G N R M T F V T E E E G
Rhesus Macaque Macaca mulatta XP_001102611 469 54028 T74 F A M G N R M T F V T E E E G
Dog Lupus familis XP_538946 469 54328 T74 F V M G N R M T F V T E E E G
Cat Felis silvestris
Mouse Mus musculus Q9JKJ9 470 53556 T77 F A M G N R M T F V S E E E G
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511640 415 47952 S37 F F K S K E V S F E L A V Q N
Chicken Gallus gallus XP_420063 419 47287 A42 R V P C L G A A F R L A R A P
Frog Xenopus laevis NP_001083508 504 57241 F108 N F T N R R N F G L S G P L E
Zebra Danio Brachydanio rerio NP_001025360 464 52846 T74 V A A G K R M T F V T L N E D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_789944 362 41142
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LTL8 498 56791 S100 R P I T N V T S K L W R D G Q
Baker's Yeast Sacchar. cerevisiae P10614 530 60702 M100 F V L L G R V M T V Y L G P K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.1 97 84.8 N.A. 74.8 N.A. N.A. 62 49.2 21.2 49.2 N.A. N.A. N.A. N.A. 23.4
Protein Similarity: 100 99.5 97.8 92.3 N.A. 86.1 N.A. N.A. 74.1 65 40.8 67.3 N.A. N.A. N.A. N.A. 39.4
P-Site Identity: 100 100 100 93.3 N.A. 93.3 N.A. N.A. 13.3 6.6 6.6 60 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 100 100 93.3 N.A. 100 N.A. N.A. 33.3 6.6 20 60 N.A. N.A. N.A. N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. 21.6 20.9 N.A.
Protein Similarity: N.A. N.A. N.A. 44.3 40.3 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 33.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 42 9 0 0 0 9 9 0 0 0 17 0 9 0 % A
% Cys: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 9 % D
% Glu: 0 0 0 0 0 9 0 0 0 9 0 42 42 50 9 % E
% Phe: 59 17 0 0 0 0 0 9 67 0 0 0 0 0 0 % F
% Gly: 0 0 0 50 9 9 0 0 9 0 0 9 9 9 42 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 9 0 17 0 0 0 9 0 0 0 0 0 9 % K
% Leu: 0 0 9 9 9 0 0 0 0 17 17 17 0 9 0 % L
% Met: 0 0 42 0 0 0 50 9 0 0 0 0 0 0 0 % M
% Asn: 9 0 0 9 50 0 9 0 0 0 0 0 9 0 9 % N
% Pro: 0 9 9 0 0 0 0 0 0 0 0 0 9 9 9 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 9 % Q
% Arg: 17 0 0 0 9 67 0 0 0 9 0 9 9 0 0 % R
% Ser: 0 0 0 9 0 0 0 17 0 0 17 0 0 0 0 % S
% Thr: 0 0 9 9 0 0 9 50 9 0 42 0 0 0 0 % T
% Val: 9 25 0 0 0 9 17 0 0 59 0 0 9 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _