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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CYP39A1
All Species:
27.27
Human Site:
Y378
Identified Species:
54.55
UniProt:
Q9NYL5
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NYL5
NP_057677.2
469
54116
Y378
W
L
H
R
N
P
K
Y
F
P
E
P
E
L
F
Chimpanzee
Pan troglodytes
XP_518518
469
54055
Y378
W
L
H
R
N
P
K
Y
F
P
E
P
E
L
F
Rhesus Macaque
Macaca mulatta
XP_001102611
469
54028
Y378
W
L
H
R
N
P
K
Y
F
P
E
P
E
L
F
Dog
Lupus familis
XP_538946
469
54328
Y378
W
L
H
R
N
P
E
Y
F
P
E
P
E
L
F
Cat
Felis silvestris
Mouse
Mus musculus
Q9JKJ9
470
53556
Y379
W
L
H
R
N
P
K
Y
F
P
E
P
E
S
F
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511640
415
47952
R335
P
E
V
F
K
P
E
R
W
K
K
A
N
L
E
Chicken
Gallus gallus
XP_420063
419
47287
R339
P
E
M
F
K
P
D
R
W
K
E
A
N
L
E
Frog
Xenopus laevis
NP_001083508
504
57241
Y410
V
L
Q
R
D
P
D
Y
W
P
E
P
E
E
F
Zebra Danio
Brachydanio rerio
NP_001025360
464
52846
Y374
W
A
H
R
N
P
K
Y
F
P
D
P
E
D
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_789944
362
41142
R289
D
R
F
R
K
E
N
R
E
K
H
H
P
C
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LTL8
498
56791
H406
S
I
G
R
D
P
K
H
W
K
N
P
E
E
F
Baker's Yeast
Sacchar. cerevisiae
P10614
530
60702
Y419
Y
T
H
L
R
D
E
Y
F
P
N
A
H
Q
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
97
84.8
N.A.
74.8
N.A.
N.A.
62
49.2
21.2
49.2
N.A.
N.A.
N.A.
N.A.
23.4
Protein Similarity:
100
99.5
97.8
92.3
N.A.
86.1
N.A.
N.A.
74.1
65
40.8
67.3
N.A.
N.A.
N.A.
N.A.
39.4
P-Site Identity:
100
100
100
93.3
N.A.
93.3
N.A.
N.A.
13.3
20
60
80
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
N.A.
N.A.
33.3
26.6
73.3
86.6
N.A.
N.A.
N.A.
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.6
20.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.3
40.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
0
0
0
0
0
25
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% C
% Asp:
9
0
0
0
17
9
17
0
0
0
9
0
0
9
0
% D
% Glu:
0
17
0
0
0
9
25
0
9
0
59
0
67
17
17
% E
% Phe:
0
0
9
17
0
0
0
0
59
0
0
0
0
0
75
% F
% Gly:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
59
0
0
0
0
9
0
0
9
9
9
0
0
% H
% Ile:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
25
0
50
0
0
34
9
0
0
0
0
% K
% Leu:
0
50
0
9
0
0
0
0
0
0
0
0
0
50
0
% L
% Met:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
50
0
9
0
0
0
17
0
17
0
0
% N
% Pro:
17
0
0
0
0
84
0
0
0
67
0
67
9
0
0
% P
% Gln:
0
0
9
0
0
0
0
0
0
0
0
0
0
9
0
% Q
% Arg:
0
9
0
75
9
0
0
25
0
0
0
0
0
0
0
% R
% Ser:
9
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% S
% Thr:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
9
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
50
0
0
0
0
0
0
0
34
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
0
0
67
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _