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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DONSON All Species: 21.82
Human Site: S542 Identified Species: 43.64
UniProt: Q9NYP3 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NYP3 NP_060083.1 566 62747 S542 P N T L E Q L S Q I P L L G K
Chimpanzee Pan troglodytes XP_001166225 566 62800 S542 P N T L E Q L S Q I P L L G K
Rhesus Macaque Macaca mulatta XP_001091031 564 62492 S540 P N T L E Q L S Q I P L L G K
Dog Lupus familis XP_535584 469 52593 Q446 K T L D Q L S Q T P I L G K S
Cat Felis silvestris
Mouse Mus musculus Q9QXP4 560 61969 S536 P K T L E Q L S Q R P V L G K
Rat Rattus norvegicus NP_001008288 488 54122 Q465 K T L E Q L S Q M P V L G K S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_416713 559 61311 S535 S K T L D Q L S Q V P T L G K
Frog Xenopus laevis Q5U4U4 579 63766 T556 P C T V E Q L T Q V N E L G K
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VNA8 568 63419 C544 P A V V G S I C R T G Q H A V
Honey Bee Apis mellifera XP_393677 572 65097 C549 S E L L K H F C S P D P A Y V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001196037 573 63812 R547 T N C G L A K R Q V E Y L G S
Poplar Tree Populus trichocarpa XP_002323361 630 68308 S603 S F G I P E A S V A P C L R S
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.2 96.4 71.5 N.A. 77.2 68.7 N.A. N.A. 62.3 59.7 N.A. N.A. 29.2 33.3 N.A. 32.2
Protein Similarity: 100 99.6 97.6 78.2 N.A. 84.8 74.5 N.A. N.A. 73.3 72 N.A. N.A. 45 53.1 N.A. 53.2
P-Site Identity: 100 100 100 6.6 N.A. 80 6.6 N.A. N.A. 66.6 60 N.A. N.A. 6.6 6.6 N.A. 26.6
P-Site Similarity: 100 100 100 13.3 N.A. 86.6 13.3 N.A. N.A. 80 80 N.A. N.A. 26.6 13.3 N.A. 33.3
Percent
Protein Identity: 20.4 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 36.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 20 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 33.3 N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 0 0 9 9 0 0 9 0 0 9 9 0 % A
% Cys: 0 9 9 0 0 0 0 17 0 0 0 9 0 0 0 % C
% Asp: 0 0 0 9 9 0 0 0 0 0 9 0 0 0 0 % D
% Glu: 0 9 0 9 42 9 0 0 0 0 9 9 0 0 0 % E
% Phe: 0 9 0 0 0 0 9 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 9 9 9 0 0 0 0 0 9 0 17 59 0 % G
% His: 0 0 0 0 0 9 0 0 0 0 0 0 9 0 0 % H
% Ile: 0 0 0 9 0 0 9 0 0 25 9 0 0 0 0 % I
% Lys: 17 17 0 0 9 0 9 0 0 0 0 0 0 17 50 % K
% Leu: 0 0 25 50 9 17 50 0 0 0 0 42 67 0 0 % L
% Met: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % M
% Asn: 0 34 0 0 0 0 0 0 0 0 9 0 0 0 0 % N
% Pro: 50 0 0 0 9 0 0 0 0 25 50 9 0 0 0 % P
% Gln: 0 0 0 0 17 50 0 17 59 0 0 9 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 9 9 9 0 0 0 9 0 % R
% Ser: 25 0 0 0 0 9 17 50 9 0 0 0 0 0 34 % S
% Thr: 9 17 50 0 0 0 0 9 9 9 0 9 0 0 0 % T
% Val: 0 0 9 17 0 0 0 0 9 25 9 9 0 0 17 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 9 0 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _