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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLEK2 All Species: 26.06
Human Site: S295 Identified Species: 57.33
UniProt: Q9NYT0 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NYT0 NP_057529.1 353 39971 S295 N R P V G G F S L R G S L V S
Chimpanzee Pan troglodytes XP_510017 563 62319 S505 N R P V G G F S L R G S L V S
Rhesus Macaque Macaca mulatta XP_001106525 353 40014 S295 N R P V G G F S L R G S L V S
Dog Lupus familis XP_537486 375 42096 S317 N R P V G G F S L R G S L V S
Cat Felis silvestris
Mouse Mus musculus Q9WV52 353 39999 S295 N R P V G G F S L R G S L V S
Rat Rattus norvegicus Q4KM33 350 39977 G288 A G G E D P L G A I H L R G C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521414 318 35933 L261 T I M K Q G Y L A K Q G H K R
Chicken Gallus gallus XP_421197 355 40406 S297 N R P V G G F S L R G C L V S
Frog Xenopus laevis NP_001080021 289 33430 S232 F F C E E N S S D D D A L F K
Zebra Danio Brachydanio rerio NP_001122211 361 40394 S303 V T P A G S V S L R G C L V S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_781827 375 42698 L312 K P L G E I P L H K C T V G V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 62.5 98.5 88.5 N.A. 95.1 39 N.A. 68.5 77.4 32.5 58.1 N.A. N.A. N.A. N.A. 32.2
Protein Similarity: 100 62.5 99.1 92 N.A. 98.8 60 N.A. 78.7 87.3 48.7 73.9 N.A. N.A. N.A. N.A. 50.1
P-Site Identity: 100 100 100 100 N.A. 100 0 N.A. 6.6 93.3 13.3 60 N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 100 100 100 N.A. 100 0 N.A. 20 93.3 20 60 N.A. N.A. N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 10 0 0 0 0 19 0 0 10 0 0 0 % A
% Cys: 0 0 10 0 0 0 0 0 0 0 10 19 0 0 10 % C
% Asp: 0 0 0 0 10 0 0 0 10 10 10 0 0 0 0 % D
% Glu: 0 0 0 19 19 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 10 10 0 0 0 0 55 0 0 0 0 0 0 10 0 % F
% Gly: 0 10 10 10 64 64 0 10 0 0 64 10 0 19 0 % G
% His: 0 0 0 0 0 0 0 0 10 0 10 0 10 0 0 % H
% Ile: 0 10 0 0 0 10 0 0 0 10 0 0 0 0 0 % I
% Lys: 10 0 0 10 0 0 0 0 0 19 0 0 0 10 10 % K
% Leu: 0 0 10 0 0 0 10 19 64 0 0 10 73 0 0 % L
% Met: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 55 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 10 64 0 0 10 10 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 10 0 0 0 0 0 10 0 0 0 0 % Q
% Arg: 0 55 0 0 0 0 0 0 0 64 0 0 10 0 10 % R
% Ser: 0 0 0 0 0 10 10 73 0 0 0 46 0 0 64 % S
% Thr: 10 10 0 0 0 0 0 0 0 0 0 10 0 0 0 % T
% Val: 10 0 0 55 0 0 10 0 0 0 0 0 10 64 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _