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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLEK2
All Species:
23.33
Human Site:
T154
Identified Species:
51.33
UniProt:
Q9NYT0
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NYT0
NP_057529.1
353
39971
T154
P
N
M
E
Q
G
S
T
Y
K
K
T
F
L
G
Chimpanzee
Pan troglodytes
XP_510017
563
62319
T364
P
N
M
E
Q
G
S
T
Y
K
K
T
F
L
G
Rhesus Macaque
Macaca mulatta
XP_001106525
353
40014
T154
P
N
M
E
Q
G
S
T
Y
K
K
T
F
L
G
Dog
Lupus familis
XP_537486
375
42096
T176
P
N
M
E
Q
G
S
T
Y
K
K
T
F
I
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9WV52
353
39999
T154
P
N
M
E
Q
G
S
T
Y
K
K
T
F
L
G
Rat
Rattus norvegicus
Q4KM33
350
39977
V151
N
L
E
K
D
K
K
V
F
N
H
C
F
T
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521414
318
35933
N132
N
S
F
K
L
P
A
N
I
S
L
N
H
I
V
Chicken
Gallus gallus
XP_421197
355
40406
R156
L
N
V
E
Q
G
N
R
Y
K
E
T
F
T
G
Frog
Xenopus laevis
NP_001080021
289
33430
T102
K
D
L
K
K
A
S
T
C
I
E
N
G
Q
R
Zebra Danio
Brachydanio rerio
NP_001122211
361
40394
S162
S
H
I
E
Q
G
S
S
Y
S
N
C
F
S
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781827
375
42698
F169
M
W
L
I
D
W
S
F
A
E
T
R
E
K
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
62.5
98.5
88.5
N.A.
95.1
39
N.A.
68.5
77.4
32.5
58.1
N.A.
N.A.
N.A.
N.A.
32.2
Protein Similarity:
100
62.5
99.1
92
N.A.
98.8
60
N.A.
78.7
87.3
48.7
73.9
N.A.
N.A.
N.A.
N.A.
50.1
P-Site Identity:
100
100
100
93.3
N.A.
100
13.3
N.A.
0
60
13.3
46.6
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
26.6
N.A.
26.6
80
46.6
66.6
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
10
0
10
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
10
0
0
19
0
0
0
% C
% Asp:
0
10
0
0
19
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
10
64
0
0
0
0
0
10
19
0
10
0
0
% E
% Phe:
0
0
10
0
0
0
0
10
10
0
0
0
73
0
0
% F
% Gly:
0
0
0
0
0
64
0
0
0
0
0
0
10
0
82
% G
% His:
0
10
0
0
0
0
0
0
0
0
10
0
10
0
0
% H
% Ile:
0
0
10
10
0
0
0
0
10
10
0
0
0
19
0
% I
% Lys:
10
0
0
28
10
10
10
0
0
55
46
0
0
10
0
% K
% Leu:
10
10
19
0
10
0
0
0
0
0
10
0
0
37
0
% L
% Met:
10
0
46
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
19
55
0
0
0
0
10
10
0
10
10
19
0
0
0
% N
% Pro:
46
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
64
0
0
0
0
0
0
0
0
10
0
% Q
% Arg:
0
0
0
0
0
0
0
10
0
0
0
10
0
0
10
% R
% Ser:
10
10
0
0
0
0
73
10
0
19
0
0
0
10
0
% S
% Thr:
0
0
0
0
0
0
0
55
0
0
10
55
0
19
0
% T
% Val:
0
0
10
0
0
0
0
10
0
0
0
0
0
0
10
% V
% Trp:
0
10
0
0
0
10
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
64
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _