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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLEK2
All Species:
17.88
Human Site:
T241
Identified Species:
39.33
UniProt:
Q9NYT0
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NYT0
NP_057529.1
353
39971
T241
K
E
E
I
S
L
S
T
V
E
L
S
G
T
V
Chimpanzee
Pan troglodytes
XP_510017
563
62319
T451
K
E
E
I
S
L
S
T
V
E
L
S
G
T
V
Rhesus Macaque
Macaca mulatta
XP_001106525
353
40014
T241
K
E
E
I
N
L
S
T
V
E
L
S
G
M
V
Dog
Lupus familis
XP_537486
375
42096
T263
K
E
E
M
S
L
S
T
M
E
L
S
G
T
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9WV52
353
39999
T241
K
E
E
I
S
L
S
T
M
E
L
S
G
T
V
Rat
Rattus norvegicus
Q4KM33
350
39977
K238
S
D
D
D
I
I
L
K
E
E
F
R
G
I
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521414
318
35933
F219
S
G
D
P
V
E
Q
F
L
D
D
S
T
A
L
Chicken
Gallus gallus
XP_421197
355
40406
I243
K
E
E
L
Q
F
N
I
S
E
L
S
G
T
I
Frog
Xenopus laevis
NP_001080021
289
33430
G189
A
S
A
L
L
N
E
G
H
L
Q
P
A
G
D
Zebra Danio
Brachydanio rerio
NP_001122211
361
40394
A249
K
A
E
K
S
R
T
A
V
E
L
S
G
K
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781827
375
42698
L256
E
E
L
P
I
K
P
L
K
G
H
G
G
K
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
62.5
98.5
88.5
N.A.
95.1
39
N.A.
68.5
77.4
32.5
58.1
N.A.
N.A.
N.A.
N.A.
32.2
Protein Similarity:
100
62.5
99.1
92
N.A.
98.8
60
N.A.
78.7
87.3
48.7
73.9
N.A.
N.A.
N.A.
N.A.
50.1
P-Site Identity:
100
100
86.6
86.6
N.A.
93.3
13.3
N.A.
6.6
53.3
0
60
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
100
93.3
100
N.A.
100
40
N.A.
33.3
73.3
6.6
66.6
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
10
0
0
0
0
10
0
0
0
0
10
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
19
10
0
0
0
0
0
10
10
0
0
0
10
% D
% Glu:
10
64
64
0
0
10
10
0
10
73
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
10
0
10
0
0
10
0
0
0
0
% F
% Gly:
0
10
0
0
0
0
0
10
0
10
0
10
82
10
0
% G
% His:
0
0
0
0
0
0
0
0
10
0
10
0
0
0
0
% H
% Ile:
0
0
0
37
19
10
0
10
0
0
0
0
0
10
28
% I
% Lys:
64
0
0
10
0
10
0
10
10
0
0
0
0
19
0
% K
% Leu:
0
0
10
19
10
46
10
10
10
10
64
0
0
0
10
% L
% Met:
0
0
0
10
0
0
0
0
19
0
0
0
0
10
0
% M
% Asn:
0
0
0
0
10
10
10
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
19
0
0
10
0
0
0
0
10
0
0
0
% P
% Gln:
0
0
0
0
10
0
10
0
0
0
10
0
0
0
0
% Q
% Arg:
0
0
0
0
0
10
0
0
0
0
0
10
0
0
0
% R
% Ser:
19
10
0
0
46
0
46
0
10
0
0
73
0
0
0
% S
% Thr:
0
0
0
0
0
0
10
46
0
0
0
0
10
46
0
% T
% Val:
0
0
0
0
10
0
0
0
37
0
0
0
0
0
55
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _