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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SIGLEC8 All Species: 3.33
Human Site: Y141 Identified Species: 14.67
UniProt: Q9NYZ4 Number Species: 5
    Phosphosite Substitution
    Charge Score: 0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NYZ4 NP_055257.2 499 54042 Y141 S Y K S Q L N Y K T K Q L S V
Chimpanzee Pan troglodytes Q95LH0 597 65057 S140 N Y K Y D Q L S V N V T A S Q
Rhesus Macaque Macaca mulatta XP_001114560 659 71990 L174 R Q H L E L S L P E R R A L R
Dog Lupus familis XP_541460 697 77324 Y276 G S Y V R Y N Y L Q N Q L S V
Cat Felis silvestris
Mouse Mus musculus Q91Y57 467 51871 I115 C S L N I R E I R K K D A G L
Rat Rattus norvegicus P07722 626 69334 D136 F S E H S V L D I I N T P N I
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 58.9 50.8 35.1 N.A. 53.1 20.9 N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 66.1 57.9 46.9 N.A. 66.5 34.9 N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 20 6.6 40 N.A. 6.6 0 N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 26.6 33.3 46.6 N.A. 26.6 26.6 N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 50 0 0 % A
% Cys: 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 17 0 0 17 0 0 0 17 0 0 0 % D
% Glu: 0 0 17 0 17 0 17 0 0 17 0 0 0 0 0 % E
% Phe: 17 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 17 0 0 0 0 0 0 0 0 0 0 0 0 17 0 % G
% His: 0 0 17 17 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 17 0 0 17 17 17 0 0 0 0 17 % I
% Lys: 0 0 34 0 0 0 0 0 17 17 34 0 0 0 0 % K
% Leu: 0 0 17 17 0 34 34 17 17 0 0 0 34 17 17 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 17 0 0 17 0 0 34 0 0 17 34 0 0 17 0 % N
% Pro: 0 0 0 0 0 0 0 0 17 0 0 0 17 0 0 % P
% Gln: 0 17 0 0 17 17 0 0 0 17 0 34 0 0 17 % Q
% Arg: 17 0 0 0 17 17 0 0 17 0 17 17 0 0 17 % R
% Ser: 17 50 0 17 17 0 17 17 0 0 0 0 0 50 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 17 0 34 0 0 0 % T
% Val: 0 0 0 17 0 17 0 0 17 0 17 0 0 0 34 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 34 17 17 0 17 0 34 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _