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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TREM2
All Species:
8.79
Human Site:
Y219
Identified Species:
32.22
UniProt:
Q9NZC2
Number Species:
6
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NZC2
NP_061838.1
230
25447
Y219
D
C
G
H
D
P
G
Y
Q
L
Q
T
L
P
G
Chimpanzee
Pan troglodytes
XP_001174118
230
25401
Y219
D
C
G
H
D
P
G
Y
Q
L
Q
T
L
P
G
Rhesus Macaque
Macaca mulatta
XP_001117305
230
25358
H219
D
C
G
H
D
P
G
H
Q
L
Q
T
L
P
G
Dog
Lupus familis
XP_851231
351
38001
Y212
D
C
S
C
D
P
G
Y
Q
L
Q
T
L
T
A
Cat
Felis silvestris
Mouse
Mus musculus
Q99NH8
227
24509
H216
D
C
G
Q
D
A
G
H
Q
L
Q
I
L
T
G
Rat
Rattus norvegicus
A2TGX5
310
34477
S296
P
D
Q
K
T
E
Y
S
E
I
R
K
P
R
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001032921
221
24903
D204
Q
V
L
R
F
P
G
D
L
V
E
H
A
H
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
96.5
50.7
N.A.
68.2
20
N.A.
N.A.
32.1
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
98.6
97.3
55.5
N.A.
76.9
33.5
N.A.
N.A.
51.2
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
73.3
N.A.
66.6
0
N.A.
N.A.
20
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
73.3
N.A.
73.3
20
N.A.
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
15
0
0
0
0
0
0
15
0
15
% A
% Cys:
0
72
0
15
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
72
15
0
0
72
0
0
15
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
15
0
0
15
0
15
0
0
0
15
% E
% Phe:
0
0
0
0
15
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
58
0
0
0
86
0
0
0
0
0
0
0
72
% G
% His:
0
0
0
43
0
0
0
29
0
0
0
15
0
15
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
15
0
15
0
0
0
% I
% Lys:
0
0
0
15
0
0
0
0
0
0
0
15
0
0
0
% K
% Leu:
0
0
15
0
0
0
0
0
15
72
0
0
72
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
15
0
0
0
0
72
0
0
0
0
0
0
15
43
0
% P
% Gln:
15
0
15
15
0
0
0
0
72
0
72
0
0
0
0
% Q
% Arg:
0
0
0
15
0
0
0
0
0
0
15
0
0
15
0
% R
% Ser:
0
0
15
0
0
0
0
15
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
15
0
0
0
0
0
0
58
0
29
0
% T
% Val:
0
15
0
0
0
0
0
0
0
15
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
15
43
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _