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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WWOX All Species: 21.21
Human Site: S401 Identified Species: 35.9
UniProt: Q9NZC7 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NZC7 NP_057457.1 414 46677 S401 A R T L W A L S E R L I Q E R
Chimpanzee Pan troglodytes XP_001144696 363 41022 S351 L A R P F T K S M V S D C L V
Rhesus Macaque Macaca mulatta XP_001105944 398 45056 L386 S C R H E F G L S N N I V L P
Dog Lupus familis XP_852623 383 43043 V371 D G R I L R P V K A I R K G S
Cat Felis silvestris
Mouse Mus musculus Q91WL8 414 46494 S401 A R A L W E L S E R L I Q D R
Rat Rattus norvegicus NP_001099658 356 40173 L344 V Y K L L F T L A R P F T K S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505354 146 16628 S133 V I V T G A N S G I G F K S G
Chicken Gallus gallus Q5F389 414 46711 S401 A V A L W E L S E R L I R E Q
Frog Xenopus laevis NP_001088080 143 16305 G131 G K V A I V T G A N T G I D T
Zebra Danio Brachydanio rerio Q803A8 412 46303 S398 A L S L W E L S E R L V Q E R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VLU5 409 46492 S396 Q Q Q L W K L S E N L I A E L
Honey Bee Apis mellifera XP_395282 414 46992 S394 A T R L W S V S Q E M I I N I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_789399 410 45991 T397 A T A L W D H T D N I I K E A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q42536 405 43844 E389 S Q E A S D V E K A R R V W E
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85.5 84.7 82.8 N.A. 93.7 81.1 N.A. 26 83 29.2 71.9 N.A. 48.3 51.2 N.A. 56.2
Protein Similarity: 100 86.2 88.4 87.4 N.A. 96.1 83.8 N.A. 29.4 93 33.3 84.3 N.A. 65.2 66.6 N.A. 73.4
P-Site Identity: 100 6.6 6.6 0 N.A. 80 13.3 N.A. 13.3 66.6 0 73.3 N.A. 53.3 33.3 N.A. 33.3
P-Site Similarity: 100 13.3 13.3 26.6 N.A. 86.6 20 N.A. 20 80 13.3 86.6 N.A. 60 60 N.A. 60
Percent
Protein Identity: N.A. N.A. N.A. 28.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 44.6 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 43 8 22 15 0 15 0 0 15 15 0 0 8 0 8 % A
% Cys: 0 8 0 0 0 0 0 0 0 0 0 0 8 0 0 % C
% Asp: 8 0 0 0 0 15 0 0 8 0 0 8 0 15 0 % D
% Glu: 0 0 8 0 8 22 0 8 36 8 0 0 0 36 8 % E
% Phe: 0 0 0 0 8 15 0 0 0 0 0 15 0 0 0 % F
% Gly: 8 8 0 0 8 0 8 8 8 0 8 8 0 8 8 % G
% His: 0 0 0 8 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 0 8 0 8 8 0 0 0 0 8 15 50 15 0 8 % I
% Lys: 0 8 8 0 0 8 8 0 15 0 0 0 22 8 0 % K
% Leu: 8 8 0 58 15 0 36 15 0 0 36 0 0 15 8 % L
% Met: 0 0 0 0 0 0 0 0 8 0 8 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 8 0 0 29 8 0 0 8 0 % N
% Pro: 0 0 0 8 0 0 8 0 0 0 8 0 0 0 8 % P
% Gln: 8 15 8 0 0 0 0 0 8 0 0 0 22 0 8 % Q
% Arg: 0 15 29 0 0 8 0 0 0 36 8 15 8 0 22 % R
% Ser: 15 0 8 0 8 8 0 58 8 0 8 0 0 8 15 % S
% Thr: 0 15 8 8 0 8 15 8 0 0 8 0 8 0 8 % T
% Val: 15 8 15 0 0 8 15 8 0 8 0 8 15 0 8 % V
% Trp: 0 0 0 0 50 0 0 0 0 0 0 0 0 8 0 % W
% Tyr: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _