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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SPG21 All Species: 50.3
Human Site: T252 Identified Species: 79.05
UniProt: Q9NZD8 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NZD8 NP_001121361.1 308 34960 T252 A R R A H L K T G G N F P Y L
Chimpanzee Pan troglodytes XP_510477 374 41733 T318 A R R A H L K T G G N F P Y L
Rhesus Macaque Macaca mulatta XP_001101919 510 57163 T454 A R R A H L K T G G N F P Y L
Dog Lupus familis XP_852491 308 35045 T252 A R R A H L K T G G N F P Y L
Cat Felis silvestris
Mouse Mus musculus Q9CQC8 308 34934 T252 A R R A H L K T G G N F P Y L
Rat Rattus norvegicus Q5XIC4 261 29557 N206 R L T L N C Q N S Y V E P H K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515770 309 35053 T252 A R R A H L K T G G N F P Y L
Chicken Gallus gallus XP_413895 310 35255 T252 A R R A H L K T G G N F P Y L
Frog Xenopus laevis Q5FVD6 310 35267 T252 A R R A H L K T G G N F P Y L
Zebra Danio Brachydanio rerio Q6PC62 311 35552 T252 A R R A H L K T G G N F P Y L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392210 292 32931 S236 D E Y A L S N S V R E E V Y K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782145 402 45740 N253 G R R A H M K N G G N F P Y L
Poplar Tree Populus trichocarpa XP_002329856 418 47206 T248 A R R A Q L K T G G D F P F L
Maize Zea mays NP_001150628 354 39212 T251 A R R A V L K T G G D F P F L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_192960 392 43529 S248 A R R A Y L K S G G D F P F L
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79.1 58.8 98.6 N.A. 97.7 81.8 N.A. 96.7 95.1 88.7 87.1 N.A. N.A. 58.1 N.A. 47.5
Protein Similarity: 100 80.4 60 99.3 N.A. 99 83.4 N.A. 98 97 93.2 93.8 N.A. N.A. 75.3 N.A. 62.9
P-Site Identity: 100 100 100 100 N.A. 100 6.6 N.A. 100 100 100 100 N.A. N.A. 13.3 N.A. 80
P-Site Similarity: 100 100 100 100 N.A. 100 26.6 N.A. 100 100 100 100 N.A. N.A. 20 N.A. 86.6
Percent
Protein Identity: 33.2 37.2 N.A. 34.6 N.A. N.A.
Protein Similarity: 48.3 55.6 N.A. 51.2 N.A. N.A.
P-Site Identity: 80 80 N.A. 73.3 N.A. N.A.
P-Site Similarity: 93.3 93.3 N.A. 100 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 80 0 0 94 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 0 0 0 0 0 0 0 0 0 20 0 0 0 0 % D
% Glu: 0 7 0 0 0 0 0 0 0 0 7 14 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 87 0 20 0 % F
% Gly: 7 0 0 0 0 0 0 0 87 87 0 0 0 0 0 % G
% His: 0 0 0 0 67 0 0 0 0 0 0 0 0 7 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 87 0 0 0 0 0 0 0 14 % K
% Leu: 0 7 0 7 7 80 0 0 0 0 0 0 0 0 87 % L
% Met: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 7 0 7 14 0 0 67 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 94 0 0 % P
% Gln: 0 0 0 0 7 0 7 0 0 0 0 0 0 0 0 % Q
% Arg: 7 87 87 0 0 0 0 0 0 7 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 7 0 14 7 0 0 0 0 0 0 % S
% Thr: 0 0 7 0 0 0 0 74 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 7 0 0 0 7 0 7 0 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 7 0 0 0 0 7 0 0 0 74 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _