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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SPG21 All Species: 40.91
Human Site: Y258 Identified Species: 64.29
UniProt: Q9NZD8 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9NZD8 NP_001121361.1 308 34960 Y258 K T G G N F P Y L C R S A E V
Chimpanzee Pan troglodytes XP_510477 374 41733 Y324 K T G G N F P Y L C R S A E V
Rhesus Macaque Macaca mulatta XP_001101919 510 57163 Y460 K T G G N F P Y L C R S A E V
Dog Lupus familis XP_852491 308 35045 Y258 K T G G N F P Y L C R S A E V
Cat Felis silvestris
Mouse Mus musculus Q9CQC8 308 34934 Y258 K T G G N F P Y L C R S A E V
Rat Rattus norvegicus Q5XIC4 261 29557 H212 Q N S Y V E P H K I R D I P V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515770 309 35053 Y258 K T G G N F P Y L C R S A E V
Chicken Gallus gallus XP_413895 310 35255 Y258 K T G G N F P Y L C R S A E V
Frog Xenopus laevis Q5FVD6 310 35267 Y258 K T G G N F P Y L C R S A E V
Zebra Danio Brachydanio rerio Q6PC62 311 35552 Y258 K T G G N F P Y L C R S A E V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392210 292 32931 Y242 N S V R E E V Y K C Y P N A K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782145 402 45740 Y259 K N G G N F P Y L C A S D E V
Poplar Tree Populus trichocarpa XP_002329856 418 47206 F254 K T G G D F P F L S R S D E V
Maize Zea mays NP_001150628 354 39212 F257 K T G G D F P F L S R P D E V
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_192960 392 43529 F254 K S G G D F P F L S R P D E V
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79.1 58.8 98.6 N.A. 97.7 81.8 N.A. 96.7 95.1 88.7 87.1 N.A. N.A. 58.1 N.A. 47.5
Protein Similarity: 100 80.4 60 99.3 N.A. 99 83.4 N.A. 98 97 93.2 93.8 N.A. N.A. 75.3 N.A. 62.9
P-Site Identity: 100 100 100 100 N.A. 100 20 N.A. 100 100 100 100 N.A. N.A. 13.3 N.A. 80
P-Site Similarity: 100 100 100 100 N.A. 100 33.3 N.A. 100 100 100 100 N.A. N.A. 20 N.A. 80
Percent
Protein Identity: 33.2 37.2 N.A. 34.6 N.A. N.A.
Protein Similarity: 48.3 55.6 N.A. 51.2 N.A. N.A.
P-Site Identity: 73.3 66.6 N.A. 60 N.A. N.A.
P-Site Similarity: 86.6 80 N.A. 80 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 7 0 60 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 74 0 0 0 0 0 % C
% Asp: 0 0 0 0 20 0 0 0 0 0 0 7 27 0 0 % D
% Glu: 0 0 0 0 7 14 0 0 0 0 0 0 0 87 0 % E
% Phe: 0 0 0 0 0 87 0 20 0 0 0 0 0 0 0 % F
% Gly: 0 0 87 87 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 7 0 0 7 0 0 % I
% Lys: 87 0 0 0 0 0 0 0 14 0 0 0 0 0 7 % K
% Leu: 0 0 0 0 0 0 0 0 87 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 14 0 0 67 0 0 0 0 0 0 0 7 0 0 % N
% Pro: 0 0 0 0 0 0 94 0 0 0 0 20 0 7 0 % P
% Gln: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 7 0 0 0 0 0 0 87 0 0 0 0 % R
% Ser: 0 14 7 0 0 0 0 0 0 20 0 74 0 0 0 % S
% Thr: 0 74 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 7 0 7 0 7 0 0 0 0 0 0 0 94 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 7 0 0 0 74 0 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _