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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DTL
All Species:
17.58
Human Site:
S259
Identified Species:
35.15
UniProt:
Q9NZJ0
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NZJ0
NP_057532.2
730
79441
S259
Y
R
Q
E
P
I
A
S
K
S
F
L
Y
P
G
Chimpanzee
Pan troglodytes
XP_525058
384
42363
Rhesus Macaque
Macaca mulatta
XP_001108416
730
79487
S259
Y
R
Q
E
P
I
A
S
K
S
F
L
Y
P
G
Dog
Lupus familis
XP_547399
730
79407
S259
Y
R
Q
E
P
I
A
S
K
S
F
L
Y
P
G
Cat
Felis silvestris
Mouse
Mus musculus
Q3TLR7
729
79113
S259
Y
R
Q
E
P
I
A
S
K
S
F
L
Y
P
G
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509630
734
80183
C260
H
K
Q
E
P
V
S
C
K
S
F
S
Y
P
G
Chicken
Gallus gallus
Q5ZJW8
720
78614
S256
Y
R
Q
D
P
V
P
S
K
S
F
F
Y
P
G
Frog
Xenopus laevis
NP_001090030
710
78256
P259
A
Y
R
Q
D
P
V
P
V
K
H
F
P
Y
P
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24371
769
84099
P263
A
Y
K
K
E
P
L
P
R
H
K
L
P
Y
A
Honey Bee
Apis mellifera
XP_395929
653
73736
R201
V
G
T
L
S
N
V
R
Q
R
R
V
I
S
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_789660
791
86742
H273
S
S
S
P
T
P
S
H
Q
F
P
Y
S
G
T
Poplar Tree
Populus trichocarpa
XP_002300052
503
55905
P52
H
N
G
E
E
T
P
P
L
S
V
S
F
C
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
52.3
98.2
93.1
N.A.
89.5
N.A.
N.A.
70.3
60.5
57.2
N.A.
N.A.
27.9
30.1
N.A.
31.3
Protein Similarity:
100
52.5
98.6
95.3
N.A.
94.5
N.A.
N.A.
80.6
71.6
70.2
N.A.
N.A.
44.9
49.1
N.A.
47.6
P-Site Identity:
100
0
100
100
N.A.
100
N.A.
N.A.
60
73.3
0
N.A.
N.A.
6.6
0
N.A.
0
P-Site Similarity:
100
0
100
100
N.A.
100
N.A.
N.A.
86.6
86.6
13.3
N.A.
N.A.
26.6
13.3
N.A.
13.3
Percent
Protein Identity:
25.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
38.9
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
0
0
0
0
34
0
0
0
0
0
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
9
0
0
0
0
0
9
0
% C
% Asp:
0
0
0
9
9
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
50
17
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
9
50
17
9
0
0
% F
% Gly:
0
9
9
0
0
0
0
0
0
0
0
0
0
9
50
% G
% His:
17
0
0
0
0
0
0
9
0
9
9
0
0
0
9
% H
% Ile:
0
0
0
0
0
34
0
0
0
0
0
0
9
0
0
% I
% Lys:
0
9
9
9
0
0
0
0
50
9
9
0
0
0
9
% K
% Leu:
0
0
0
9
0
0
9
0
9
0
0
42
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
0
0
0
9
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
9
50
25
17
25
0
0
9
0
17
50
9
% P
% Gln:
0
0
50
9
0
0
0
0
17
0
0
0
0
0
0
% Q
% Arg:
0
42
9
0
0
0
0
9
9
9
9
0
0
0
0
% R
% Ser:
9
9
9
0
9
0
17
42
0
59
0
17
9
9
0
% S
% Thr:
0
0
9
0
9
9
0
0
0
0
0
0
0
0
9
% T
% Val:
9
0
0
0
0
17
17
0
9
0
9
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
42
17
0
0
0
0
0
0
0
0
0
9
50
17
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _