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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DTL
All Species:
12.73
Human Site:
S599
Identified Species:
25.45
UniProt:
Q9NZJ0
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NZJ0
NP_057532.2
730
79441
S599
A
G
N
Q
E
D
L
S
K
D
S
L
G
P
T
Chimpanzee
Pan troglodytes
XP_525058
384
42363
S259
Y
R
Q
E
P
I
A
S
K
S
F
L
Y
P
G
Rhesus Macaque
Macaca mulatta
XP_001108416
730
79487
S599
A
G
N
Q
E
D
L
S
K
D
S
L
G
P
T
Dog
Lupus familis
XP_547399
730
79407
G599
A
G
N
Q
E
D
L
G
K
D
S
L
V
P
T
Cat
Felis silvestris
Mouse
Mus musculus
Q3TLR7
729
79113
S598
S
G
T
Q
E
V
L
S
Q
D
S
E
G
P
T
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509630
734
80183
G599
L
A
G
N
Q
G
S
G
E
D
C
L
S
L
T
Chicken
Gallus gallus
Q5ZJW8
720
78614
R593
C
H
L
A
A
G
Q
R
A
C
D
E
G
S
L
Frog
Xenopus laevis
NP_001090030
710
78256
K585
L
D
V
C
F
I
D
K
E
R
D
S
S
D
D
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24371
769
84099
S633
I
R
K
Q
K
L
M
S
G
R
A
H
V
T
L
Honey Bee
Apis mellifera
XP_395929
653
73736
G527
N
N
S
L
L
N
R
G
Y
E
S
D
E
P
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_789660
791
86742
D633
G
A
I
M
G
T
D
D
K
D
L
V
K
D
T
Poplar Tree
Populus trichocarpa
XP_002300052
503
55905
T378
A
T
S
S
D
D
F
T
V
R
I
W
N
I
N
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
52.3
98.2
93.1
N.A.
89.5
N.A.
N.A.
70.3
60.5
57.2
N.A.
N.A.
27.9
30.1
N.A.
31.3
Protein Similarity:
100
52.5
98.6
95.3
N.A.
94.5
N.A.
N.A.
80.6
71.6
70.2
N.A.
N.A.
44.9
49.1
N.A.
47.6
P-Site Identity:
100
26.6
100
86.6
N.A.
66.6
N.A.
N.A.
20
6.6
0
N.A.
N.A.
13.3
20
N.A.
20
P-Site Similarity:
100
33.3
100
86.6
N.A.
80
N.A.
N.A.
33.3
6.6
6.6
N.A.
N.A.
33.3
40
N.A.
26.6
Percent
Protein Identity:
25.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
38.9
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
34
17
0
9
9
0
9
0
9
0
9
0
0
0
0
% A
% Cys:
9
0
0
9
0
0
0
0
0
9
9
0
0
0
0
% C
% Asp:
0
9
0
0
9
34
17
9
0
50
17
9
0
17
9
% D
% Glu:
0
0
0
9
34
0
0
0
17
9
0
17
9
0
0
% E
% Phe:
0
0
0
0
9
0
9
0
0
0
9
0
0
0
0
% F
% Gly:
9
34
9
0
9
17
0
25
9
0
0
0
34
0
9
% G
% His:
0
9
0
0
0
0
0
0
0
0
0
9
0
0
0
% H
% Ile:
9
0
9
0
0
17
0
0
0
0
9
0
0
9
0
% I
% Lys:
0
0
9
0
9
0
0
9
42
0
0
0
9
0
0
% K
% Leu:
17
0
9
9
9
9
34
0
0
0
9
42
0
9
17
% L
% Met:
0
0
0
9
0
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
9
9
25
9
0
9
0
0
0
0
0
0
9
0
9
% N
% Pro:
0
0
0
0
9
0
0
0
0
0
0
0
0
50
0
% P
% Gln:
0
0
9
42
9
0
9
0
9
0
0
0
0
0
0
% Q
% Arg:
0
17
0
0
0
0
9
9
0
25
0
0
0
0
0
% R
% Ser:
9
0
17
9
0
0
9
42
0
9
42
9
17
9
0
% S
% Thr:
0
9
9
0
0
9
0
9
0
0
0
0
0
9
59
% T
% Val:
0
0
9
0
0
9
0
0
9
0
0
9
17
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% W
% Tyr:
9
0
0
0
0
0
0
0
9
0
0
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _