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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DTL
All Species:
13.64
Human Site:
T635
Identified Species:
27.27
UniProt:
Q9NZJ0
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NZJ0
NP_057532.2
730
79441
T635
Y
A
S
E
S
C
G
T
L
P
L
P
L
R
P
Chimpanzee
Pan troglodytes
XP_525058
384
42363
I295
A
N
C
T
D
D
N
I
Y
M
F
N
M
T
G
Rhesus Macaque
Macaca mulatta
XP_001108416
730
79487
T635
Y
A
S
E
S
C
G
T
L
P
L
P
L
R
P
Dog
Lupus familis
XP_547399
730
79407
T635
Y
A
S
E
S
C
G
T
L
P
L
P
L
G
S
Cat
Felis silvestris
Mouse
Mus musculus
Q3TLR7
729
79113
P634
Y
A
S
E
G
C
G
P
L
P
L
P
L
R
P
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509630
734
80183
S635
L
S
P
E
D
F
S
S
P
T
L
P
S
K
S
Chicken
Gallus gallus
Q5ZJW8
720
78614
S629
P
G
S
L
V
N
P
S
G
T
Q
T
P
P
P
Frog
Xenopus laevis
NP_001090030
710
78256
T621
T
S
L
H
M
N
A
T
E
N
L
L
Q
L
G
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24371
769
84099
R669
R
Q
S
E
C
S
P
R
I
H
A
S
P
R
R
Honey Bee
Apis mellifera
XP_395929
653
73736
T563
P
N
F
V
I
D
G
T
A
P
H
L
L
Q
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_789660
791
86742
G669
D
Y
S
G
N
C
D
G
I
D
K
E
N
L
N
Poplar Tree
Populus trichocarpa
XP_002300052
503
55905
L414
P
R
E
E
C
R
E
L
L
M
N
D
E
R
I
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
52.3
98.2
93.1
N.A.
89.5
N.A.
N.A.
70.3
60.5
57.2
N.A.
N.A.
27.9
30.1
N.A.
31.3
Protein Similarity:
100
52.5
98.6
95.3
N.A.
94.5
N.A.
N.A.
80.6
71.6
70.2
N.A.
N.A.
44.9
49.1
N.A.
47.6
P-Site Identity:
100
0
100
86.6
N.A.
86.6
N.A.
N.A.
20
13.3
13.3
N.A.
N.A.
20
26.6
N.A.
13.3
P-Site Similarity:
100
6.6
100
86.6
N.A.
86.6
N.A.
N.A.
40
20
20
N.A.
N.A.
26.6
33.3
N.A.
26.6
Percent
Protein Identity:
25.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
38.9
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
20
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
20
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
34
0
0
0
0
9
0
9
0
9
0
0
0
0
% A
% Cys:
0
0
9
0
17
42
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
17
17
9
0
0
9
0
9
0
0
0
% D
% Glu:
0
0
9
59
0
0
9
0
9
0
0
9
9
0
0
% E
% Phe:
0
0
9
0
0
9
0
0
0
0
9
0
0
0
0
% F
% Gly:
0
9
0
9
9
0
42
9
9
0
0
0
0
9
17
% G
% His:
0
0
0
9
0
0
0
0
0
9
9
0
0
0
0
% H
% Ile:
0
0
0
0
9
0
0
9
17
0
0
0
0
0
9
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
9
0
0
9
0
% K
% Leu:
9
0
9
9
0
0
0
9
42
0
50
17
42
17
9
% L
% Met:
0
0
0
0
9
0
0
0
0
17
0
0
9
0
0
% M
% Asn:
0
17
0
0
9
17
9
0
0
9
9
9
9
0
9
% N
% Pro:
25
0
9
0
0
0
17
9
9
42
0
42
17
9
34
% P
% Gln:
0
9
0
0
0
0
0
0
0
0
9
0
9
9
0
% Q
% Arg:
9
9
0
0
0
9
0
9
0
0
0
0
0
42
9
% R
% Ser:
0
17
59
0
25
9
9
17
0
0
0
9
9
0
17
% S
% Thr:
9
0
0
9
0
0
0
42
0
17
0
9
0
9
0
% T
% Val:
0
0
0
9
9
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
34
9
0
0
0
0
0
0
9
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _