KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK3
All Species:
25.15
Human Site:
S1096
Identified Species:
46.11
UniProt:
Q9NZJ5
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NZJ5
NP_004827
1115
125147
S1096
R
Q
R
S
R
S
L
S
S
S
G
T
K
H
S
Chimpanzee
Pan troglodytes
XP_001140984
1115
125149
S1095
R
Q
R
S
R
S
L
S
S
S
G
T
K
H
S
Rhesus Macaque
Macaca mulatta
XP_001094493
1115
124992
S1095
R
Q
R
S
R
S
L
S
S
S
G
T
K
H
S
Dog
Lupus familis
XP_854775
1113
124420
S1093
R
Q
R
S
R
S
M
S
S
S
G
T
K
H
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B5
1114
124664
S1094
R
Q
R
S
R
S
M
S
S
S
G
T
K
H
S
Rat
Rattus norvegicus
Q9Z1Z1
1108
124752
S1088
R
Q
R
S
R
S
L
S
S
S
G
T
K
H
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512022
1122
125919
S1091
K
V
D
R
R
P
P
S
P
Q
Q
G
K
V
H
Chicken
Gallus gallus
XP_420868
1085
121590
L1065
E
L
P
A
K
P
V
L
R
Q
R
S
R
T
M
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001070617
323
35609
S304
Q
F
C
T
P
I
A
S
A
W
L
V
G
G
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NIV1
1162
131020
Q1138
L
S
E
G
Q
S
E
Q
A
E
L
A
E
R
A
Honey Bee
Apis mellifera
XP_001123105
822
95490
F803
N
E
N
T
K
W
H
F
E
L
P
Q
L
T
Q
Nematode Worm
Caenorhab. elegans
Q19192
1077
119621
Q1055
E
S
R
D
F
L
L
Q
L
T
S
L
E
P
S
Sea Urchin
Strong. purpuratus
XP_001196022
1233
137177
D1190
A
K
W
L
L
S
H
D
P
D
L
R
P
D
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.8
91.7
N.A.
87.6
87.4
N.A.
75.4
76.8
N.A.
20.7
N.A.
32.7
31
22.1
31.9
Protein Similarity:
100
99.7
98.9
94.9
N.A.
92.4
93.1
N.A.
82.1
84.9
N.A.
24.8
N.A.
50.8
48.2
40.4
50.9
P-Site Identity:
100
100
100
93.3
N.A.
93.3
100
N.A.
20
0
N.A.
6.6
N.A.
6.6
0
20
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
26.6
33.3
N.A.
26.6
N.A.
33.3
20
33.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
0
0
8
0
16
0
0
8
0
0
8
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
8
0
0
0
8
0
8
0
0
0
8
0
% D
% Glu:
16
8
8
0
0
0
8
0
8
8
0
0
16
0
0
% E
% Phe:
0
8
0
0
8
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
0
0
0
0
47
8
8
8
8
% G
% His:
0
0
0
0
0
0
16
0
0
0
0
0
0
47
8
% H
% Ile:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
8
0
0
16
0
0
0
0
0
0
0
54
0
0
% K
% Leu:
8
8
0
8
8
8
39
8
8
8
24
8
8
0
0
% L
% Met:
0
0
0
0
0
0
16
0
0
0
0
0
0
0
8
% M
% Asn:
8
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
8
0
8
16
8
0
16
0
8
0
8
8
0
% P
% Gln:
8
47
0
0
8
0
0
16
0
16
8
8
0
0
8
% Q
% Arg:
47
0
54
8
54
0
0
0
8
0
8
8
8
8
0
% R
% Ser:
0
16
0
47
0
62
0
62
47
47
8
8
0
0
54
% S
% Thr:
0
0
0
16
0
0
0
0
0
8
0
47
0
16
8
% T
% Val:
0
8
0
0
0
0
8
0
0
0
0
8
0
8
0
% V
% Trp:
0
0
8
0
0
8
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _