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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK3
All Species:
22.73
Human Site:
S848
Identified Species:
41.67
UniProt:
Q9NZJ5
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NZJ5
NP_004827
1115
125147
S848
K
P
T
S
S
K
S
S
S
E
A
T
L
S
I
Chimpanzee
Pan troglodytes
XP_001140984
1115
125149
S847
K
P
T
S
S
K
S
S
S
E
A
T
L
S
I
Rhesus Macaque
Macaca mulatta
XP_001094493
1115
124992
S847
K
P
T
S
S
K
S
S
S
E
A
T
L
S
I
Dog
Lupus familis
XP_854775
1113
124420
S845
K
H
S
S
S
K
S
S
S
E
P
T
F
S
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B5
1114
124664
S844
L
K
C
S
S
S
R
S
S
S
E
A
T
T
L
Rat
Rattus norvegicus
Q9Z1Z1
1108
124752
S840
K
H
S
S
S
R
S
S
S
E
A
T
L
S
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512022
1122
125919
L857
K
D
S
P
S
E
S
L
L
S
I
S
P
P
R
Chicken
Gallus gallus
XP_420868
1085
121590
S825
K
E
P
G
N
K
K
S
S
G
S
P
L
S
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001070617
323
35609
D74
G
R
K
Q
W
D
L
D
V
G
S
G
C
L
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NIV1
1162
131020
L896
R
K
P
L
T
L
A
L
A
Q
N
H
N
N
N
Honey Bee
Apis mellifera
XP_001123105
822
95490
I573
N
N
S
T
H
S
E
I
N
L
N
N
K
S
N
Nematode Worm
Caenorhab. elegans
Q19192
1077
119621
Y816
I
D
D
E
P
K
K
Y
N
S
S
S
G
G
I
Sea Urchin
Strong. purpuratus
XP_001196022
1233
137177
G948
Q
I
V
F
E
D
S
G
C
T
D
Q
P
R
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.8
91.7
N.A.
87.6
87.4
N.A.
75.4
76.8
N.A.
20.7
N.A.
32.7
31
22.1
31.9
Protein Similarity:
100
99.7
98.9
94.9
N.A.
92.4
93.1
N.A.
82.1
84.9
N.A.
24.8
N.A.
50.8
48.2
40.4
50.9
P-Site Identity:
100
100
100
66.6
N.A.
26.6
73.3
N.A.
20
40
N.A.
0
N.A.
0
6.6
13.3
6.6
P-Site Similarity:
100
100
100
80
N.A.
40
86.6
N.A.
40
60
N.A.
13.3
N.A.
40
26.6
33.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
8
0
31
8
0
0
0
% A
% Cys:
0
0
8
0
0
0
0
0
8
0
0
0
8
0
0
% C
% Asp:
0
16
8
0
0
16
0
8
0
0
8
0
0
0
0
% D
% Glu:
0
8
0
8
8
8
8
0
0
39
8
0
0
0
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
0
0
8
0
0
% F
% Gly:
8
0
0
8
0
0
0
8
0
16
0
8
8
8
0
% G
% His:
0
16
0
0
8
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
8
8
0
0
0
0
0
8
0
0
8
0
0
0
31
% I
% Lys:
54
16
8
0
0
47
16
0
0
0
0
0
8
0
0
% K
% Leu:
8
0
0
8
0
8
8
16
8
8
0
0
39
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
8
0
0
8
0
0
0
16
0
16
8
8
8
16
% N
% Pro:
0
24
16
8
8
0
0
0
0
0
8
8
16
8
0
% P
% Gln:
8
0
0
8
0
0
0
0
0
8
0
8
0
0
0
% Q
% Arg:
8
8
0
0
0
8
8
0
0
0
0
0
0
8
8
% R
% Ser:
0
0
31
47
54
16
54
54
54
24
24
16
0
54
0
% S
% Thr:
0
0
24
8
8
0
0
0
0
8
0
39
8
8
8
% T
% Val:
0
0
8
0
0
0
0
0
8
0
0
0
0
0
24
% V
% Trp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _