KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK3
All Species:
23.64
Human Site:
T861
Identified Species:
43.33
UniProt:
Q9NZJ5
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NZJ5
NP_004827
1115
125147
T861
S
I
S
P
P
R
P
T
T
L
S
L
D
L
T
Chimpanzee
Pan troglodytes
XP_001140984
1115
125149
T860
S
I
S
P
P
R
P
T
T
L
S
L
D
L
T
Rhesus Macaque
Macaca mulatta
XP_001094493
1115
124992
T860
S
I
S
P
P
R
P
T
T
L
S
L
D
L
T
Dog
Lupus familis
XP_854775
1113
124420
T858
S
V
S
P
P
R
P
T
T
L
S
L
D
L
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2B5
1114
124664
R857
T
L
S
T
S
P
T
R
P
T
T
L
S
L
D
Rat
Rattus norvegicus
Q9Z1Z1
1108
124752
T853
S
T
S
P
T
R
P
T
T
L
S
L
D
F
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512022
1122
125919
L870
P
R
P
T
T
L
S
L
D
L
T
R
N
V
T
Chicken
Gallus gallus
XP_420868
1085
121590
T838
S
V
S
P
P
R
P
T
S
L
S
L
D
L
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001070617
323
35609
K87
L
V
S
S
S
L
S
K
P
E
I
F
G
N
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NIV1
1162
131020
P909
N
N
Q
N
G
S
Q
P
T
P
S
S
A
T
I
Honey Bee
Apis mellifera
XP_001123105
822
95490
K586
S
N
T
H
K
S
P
K
M
F
L
Y
I
Q
M
Nematode Worm
Caenorhab. elegans
Q19192
1077
119621
S829
G
I
E
F
V
D
G
S
D
D
V
D
N
E
A
Sea Urchin
Strong. purpuratus
XP_001196022
1233
137177
T961
R
Y
S
D
S
E
S
T
Q
S
D
T
S
K
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.8
91.7
N.A.
87.6
87.4
N.A.
75.4
76.8
N.A.
20.7
N.A.
32.7
31
22.1
31.9
Protein Similarity:
100
99.7
98.9
94.9
N.A.
92.4
93.1
N.A.
82.1
84.9
N.A.
24.8
N.A.
50.8
48.2
40.4
50.9
P-Site Identity:
100
100
100
86.6
N.A.
20
80
N.A.
13.3
80
N.A.
6.6
N.A.
13.3
13.3
6.6
13.3
P-Site Similarity:
100
100
100
100
N.A.
40
80
N.A.
33.3
100
N.A.
13.3
N.A.
20
20
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
8
0
0
16
8
8
8
47
0
8
% D
% Glu:
0
0
8
0
0
8
0
0
0
8
0
0
0
8
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
8
0
8
0
8
0
% F
% Gly:
8
0
0
0
8
0
8
0
0
0
0
0
8
0
0
% G
% His:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
31
0
0
0
0
0
0
0
0
8
0
8
0
8
% I
% Lys:
0
0
0
0
8
0
0
16
0
0
0
0
0
8
8
% K
% Leu:
8
8
0
0
0
16
0
8
0
54
8
54
0
47
0
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
8
% M
% Asn:
8
16
0
8
0
0
0
0
0
0
0
0
16
8
0
% N
% Pro:
8
0
8
47
39
8
54
8
16
8
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
8
0
8
0
0
0
0
8
0
% Q
% Arg:
8
8
0
0
0
47
0
8
0
0
0
8
0
0
0
% R
% Ser:
54
0
70
8
24
16
24
8
8
8
54
8
16
0
24
% S
% Thr:
8
8
8
16
16
0
8
54
47
8
16
8
0
8
39
% T
% Val:
0
24
0
0
8
0
0
0
0
0
8
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _