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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MARK1
All Species:
14.85
Human Site:
T473
Identified Species:
27.22
UniProt:
Q9P0L2
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P0L2
NP_061120.3
795
89003
T473
V
G
S
K
S
E
M
T
A
S
P
L
V
G
P
Chimpanzee
Pan troglodytes
XP_001172839
796
89049
A474
G
S
K
S
E
M
T
A
S
P
L
V
G
P
E
Rhesus Macaque
Macaca mulatta
XP_001115611
778
86745
P458
K
V
P
A
S
P
L
P
G
L
E
R
K
K
T
Dog
Lupus familis
XP_536123
782
87409
T460
V
G
S
K
S
E
M
T
A
S
P
L
V
G
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8VHJ5
795
88528
T473
V
G
S
K
S
E
V
T
A
S
P
L
V
G
P
Rat
Rattus norvegicus
O08678
793
88216
T473
V
G
S
K
S
E
V
T
A
S
P
L
V
G
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511751
793
88836
M471
T
V
G
S
K
G
E
M
A
V
S
P
L
V
G
Chicken
Gallus gallus
Q9IA88
798
88848
V447
E
T
T
I
S
E
E
V
R
Q
E
K
E
L
E
Frog
Xenopus laevis
NP_001085126
792
88624
V473
V
N
S
K
G
E
V
V
A
S
P
L
A
G
P
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
R601
T
L
H
L
P
M
E
R
F
S
P
V
R
R
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
T870
G
G
P
P
Q
R
A
T
S
Q
Q
M
S
R
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
V201
Y
A
G
P
E
V
D
V
W
S
C
G
V
I
L
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
H322
L
P
P
D
L
K
P
H
P
E
E
E
N
E
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
68.9
95.9
N.A.
94.9
94.3
N.A.
92.8
30.4
88.6
27.8
N.A.
N.A.
N.A.
40.7
N.A.
Protein Similarity:
100
99.3
80.2
96.8
N.A.
97.3
96.9
N.A.
95.9
51.3
94.2
44
N.A.
N.A.
N.A.
51
N.A.
P-Site Identity:
100
0
6.6
100
N.A.
93.3
93.3
N.A.
6.6
13.3
66.6
13.3
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
13.3
13.3
100
N.A.
100
100
N.A.
13.3
20
73.3
20
N.A.
N.A.
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.9
28
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.4
46.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
0
0
8
8
47
0
0
0
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% D
% Glu:
8
0
0
0
16
47
24
0
0
8
24
8
8
8
16
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
8
% F
% Gly:
16
39
16
0
8
8
0
0
8
0
0
8
8
39
8
% G
% His:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
0
% I
% Lys:
8
0
8
39
8
8
0
0
0
0
0
8
8
8
0
% K
% Leu:
8
8
0
8
8
0
8
0
0
8
8
39
8
8
8
% L
% Met:
0
0
0
0
0
16
16
8
0
0
0
8
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
0
0
0
0
0
8
0
8
% N
% Pro:
0
8
24
16
8
8
8
8
8
8
47
8
0
8
39
% P
% Gln:
0
0
0
0
8
0
0
0
0
16
8
0
0
0
0
% Q
% Arg:
0
0
0
0
0
8
0
8
8
0
0
8
8
16
0
% R
% Ser:
0
8
39
16
47
0
0
0
16
54
8
0
8
0
8
% S
% Thr:
16
8
8
0
0
0
8
39
0
0
0
0
0
0
8
% T
% Val:
39
16
0
0
0
8
24
24
0
8
0
16
39
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _