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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VPS18
All Species:
34.55
Human Site:
T274
Identified Species:
58.46
UniProt:
Q9P253
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P253
NP_065908.1
973
110186
T274
Y
S
E
L
A
F
Y
T
P
K
L
R
S
A
P
Chimpanzee
Pan troglodytes
XP_523187
973
110161
T274
Y
S
E
L
A
F
Y
T
P
K
L
R
S
A
P
Rhesus Macaque
Macaca mulatta
XP_001099146
973
110096
T274
Y
S
E
L
A
F
Y
T
P
K
L
R
S
A
P
Dog
Lupus familis
XP_544627
1095
122945
T396
Y
S
E
L
A
F
Y
T
P
K
L
R
S
A
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8R307
973
110200
T274
Y
S
E
L
A
F
Y
T
P
K
L
R
S
A
P
Rat
Rattus norvegicus
NP_001099969
973
110167
T274
Y
S
E
L
A
F
Y
T
P
K
L
R
S
A
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506026
612
69591
Chicken
Gallus gallus
XP_421131
974
112556
T274
F
S
E
I
A
F
Y
T
P
K
L
R
S
N
P
Frog
Xenopus laevis
NP_001085645
968
111576
T273
Y
S
E
I
A
F
Y
T
Q
K
L
R
S
I
P
Zebra Danio
Brachydanio rerio
P59015
974
113248
T274
Y
S
E
I
T
F
Y
T
S
K
L
R
S
R
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24314
1002
115316
A294
F
S
Q
L
R
F
F
A
P
P
N
S
K
Y
P
Honey Bee
Apis mellifera
XP_396968
718
83450
D108
N
Q
D
L
I
F
E
D
I
Y
N
D
A
V
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_172709
994
113061
C245
R
I
K
E
I
T
K
C
N
S
T
L
L
T
W
Baker's Yeast
Sacchar. cerevisiae
P27801
918
107380
F247
S
S
K
V
L
L
N
F
E
L
P
D
Y
Q
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99.6
86.6
N.A.
95.7
95.1
N.A.
52.8
74
68.3
65.9
N.A.
34.7
34.6
N.A.
N.A.
Protein Similarity:
100
99.9
99.9
87.4
N.A.
97.5
97.1
N.A.
56.4
86.4
83.2
82.4
N.A.
53.6
51.4
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
80
80
73.3
N.A.
33.3
13.3
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
0
93.3
86.6
80
N.A.
53.3
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
32.7
21.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
52.3
41.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
58
0
0
8
0
0
0
0
8
43
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
0
8
0
0
0
15
0
0
0
% D
% Glu:
0
0
65
8
0
0
8
0
8
0
0
0
0
0
0
% E
% Phe:
15
0
0
0
0
79
8
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
22
15
0
0
0
8
0
0
0
0
8
0
% I
% Lys:
0
0
15
0
0
0
8
0
0
65
0
0
8
0
0
% K
% Leu:
0
0
0
58
8
8
0
0
0
8
65
8
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
8
0
8
0
15
0
0
8
8
% N
% Pro:
0
0
0
0
0
0
0
0
58
8
8
0
0
0
72
% P
% Gln:
0
8
8
0
0
0
0
0
8
0
0
0
0
8
0
% Q
% Arg:
8
0
0
0
8
0
0
0
0
0
0
65
0
8
0
% R
% Ser:
8
79
0
0
0
0
0
0
8
8
0
8
65
0
0
% S
% Thr:
0
0
0
0
8
8
0
65
0
0
8
0
0
8
0
% T
% Val:
0
0
0
8
0
0
0
0
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
58
0
0
0
0
0
65
0
0
8
0
0
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _