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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LARS All Species: 19.09
Human Site: S544 Identified Species: 35
UniProt: Q9P2J5 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9P2J5 NP_064502.9 1176 134466 S544 E N W K K Q T S Q C L K N L E
Chimpanzee Pan troglodytes XP_001157096 1176 134469 S544 E N W K K Q T S Q C L K N L E
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_535229 1176 134216 S544 E N W K K Q T S Q C L K G L E
Cat Felis silvestris
Mouse Mus musculus Q8BMJ2 1178 134174 F546 E N W K K Q T F Q C L K N M E
Rat Rattus norvegicus NP_001009637 1178 134260 F546 E N W K K Q T F Q C L K N M E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_414663 1177 134257 S545 V D W K K Q T S E C L K Q L E
Frog Xenopus laevis NP_001087393 1178 134087 T546 A K W K E Q T T E C L K N L E
Zebra Danio Brachydanio rerio XP_698279 747 84899 G184 T V A H L L Q G G V L S G Q G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_787968 1182 134854 T544 P E W Q A Q A T K I L H G M E
Honey Bee Apis mellifera XP_395743 1181 136743 I542 E T W K K E A I E A L N N L N
Nematode Worm Caenorhab. elegans Q09996 1186 134501 K545 A E W K A A A K K V L E P L R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P26637 1090 124123 P526 E A F V Y N E P E S Q V M S R
Red Bread Mold Neurospora crassa P10857 1123 126381 G554 N K V V S R S G D E C S V A L
Conservation
Percent
Protein Identity: 100 99.5 N.A. 94.9 N.A. 90 89.9 N.A. N.A. 87 82.5 50.5 N.A. 59.3 60.9 56.6 N.A.
Protein Similarity: 100 99.9 N.A. 97.5 N.A. 96.1 96 N.A. N.A. 93.5 92.6 57.4 N.A. 75.3 78.2 71.4 N.A.
P-Site Identity: 100 100 N.A. 93.3 N.A. 86.6 86.6 N.A. N.A. 73.3 66.6 6.6 N.A. 26.6 46.6 26.6 N.A.
P-Site Similarity: 100 100 N.A. 93.3 N.A. 93.3 93.3 N.A. N.A. 86.6 86.6 6.6 N.A. 53.3 60 40 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 43.7 43.8
Protein Similarity: N.A. N.A. N.A. N.A. 61.1 61.6
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 0
P-Site Similarity: N.A. N.A. N.A. N.A. 20 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 8 8 0 16 8 24 0 0 8 0 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 54 8 0 0 0 0 % C
% Asp: 0 8 0 0 0 0 0 0 8 0 0 0 0 0 0 % D
% Glu: 54 16 0 0 8 8 8 0 31 8 0 8 0 0 62 % E
% Phe: 0 0 8 0 0 0 0 16 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 16 8 0 0 0 24 0 8 % G
% His: 0 0 0 8 0 0 0 0 0 0 0 8 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 8 0 8 0 0 0 0 0 % I
% Lys: 0 16 0 70 54 0 0 8 16 0 0 54 0 0 0 % K
% Leu: 0 0 0 0 8 8 0 0 0 0 85 0 0 54 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 8 24 0 % M
% Asn: 8 39 0 0 0 8 0 0 0 0 0 8 47 0 8 % N
% Pro: 8 0 0 0 0 0 0 8 0 0 0 0 8 0 0 % P
% Gln: 0 0 0 8 0 62 8 0 39 0 8 0 8 8 0 % Q
% Arg: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 16 % R
% Ser: 0 0 0 0 8 0 8 31 0 8 0 16 0 8 0 % S
% Thr: 8 8 0 0 0 0 54 16 0 0 0 0 0 0 0 % T
% Val: 8 8 8 16 0 0 0 0 0 16 0 8 8 0 0 % V
% Trp: 0 0 77 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _