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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK4
All Species:
18.18
Human Site:
S641
Identified Species:
40
UniProt:
Q9P2K8
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P2K8
NP_001013725.2
1649
186838
S641
K
G
E
V
T
L
L
S
R
L
H
H
E
N
I
Chimpanzee
Pan troglodytes
XP_001140245
1649
186793
S641
K
G
E
V
T
L
L
S
R
L
H
H
E
N
I
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535431
1633
184740
S641
K
G
E
V
T
L
L
S
R
L
H
H
E
N
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ05
1648
186468
S640
K
G
E
V
T
L
L
S
R
L
H
H
E
N
I
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518247
1608
180821
S601
K
G
E
V
T
L
L
S
R
L
N
H
E
N
I
Chicken
Gallus gallus
XP_421203
1656
188583
G647
K
Q
F
R
R
I
K
G
E
V
T
L
L
S
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667149
1483
168725
V539
G
K
G
A
F
G
A
V
I
K
V
Q
N
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120977
1130
130476
L186
I
E
K
L
A
P
P
L
H
E
V
E
W
N
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785160
1605
181469
K655
G
N
L
Y
A
I
K
K
I
L
L
N
P
K
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LX30
1241
140303
Q297
E
K
K
E
S
N
L
Q
D
D
T
A
E
D
D
Baker's Yeast
Sacchar. cerevisiae
P15442
1659
190175
V614
Q
G
A
F
G
Q
V
V
K
A
R
N
A
L
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
N.A.
89.7
N.A.
90.5
N.A.
N.A.
74.7
72.3
N.A.
52.6
N.A.
N.A.
27.9
N.A.
40.4
Protein Similarity:
100
99.9
N.A.
94.3
N.A.
94.9
N.A.
N.A.
84.4
84.5
N.A.
67.4
N.A.
N.A.
44
N.A.
59.4
P-Site Identity:
100
100
N.A.
100
N.A.
100
N.A.
N.A.
93.3
6.6
N.A.
0
N.A.
N.A.
6.6
N.A.
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
N.A.
N.A.
100
26.6
N.A.
6.6
N.A.
N.A.
26.6
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.5
26.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.7
46.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
10
19
0
10
0
0
10
0
10
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
10
10
0
0
0
10
19
% D
% Glu:
10
10
46
10
0
0
0
0
10
10
0
10
55
0
0
% E
% Phe:
0
0
10
10
10
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
19
55
10
0
10
10
0
10
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
10
0
37
46
0
0
0
% H
% Ile:
10
0
0
0
0
19
0
0
19
0
0
0
0
0
46
% I
% Lys:
55
19
19
0
0
0
19
10
10
10
0
0
0
19
0
% K
% Leu:
0
0
10
10
0
46
55
10
0
55
10
10
10
10
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
10
0
0
0
0
10
19
10
55
0
% N
% Pro:
0
0
0
0
0
10
10
0
0
0
0
0
10
0
0
% P
% Gln:
10
10
0
0
0
10
0
10
0
0
0
10
0
0
0
% Q
% Arg:
0
0
0
10
10
0
0
0
46
0
10
0
0
0
10
% R
% Ser:
0
0
0
0
10
0
0
46
0
0
0
0
0
10
10
% S
% Thr:
0
0
0
0
46
0
0
0
0
0
19
0
0
0
0
% T
% Val:
0
0
0
46
0
0
10
19
0
10
19
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% W
% Tyr:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _