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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2AK4 All Species: 17.58
Human Site: T1085 Identified Species: 38.67
UniProt: Q9P2K8 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9P2K8 NP_001013725.2 1649 186838 T1085 H G A V Q L C T P L L L P R N
Chimpanzee Pan troglodytes XP_001140245 1649 186793 T1085 H G A V Q L C T P L L L P R N
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_535431 1633 184740 P1088 G A V Q L C T P L L L P Q N R
Cat Felis silvestris
Mouse Mus musculus Q9QZ05 1648 186468 T1084 H G A V Q L C T P L L L P R N
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518247 1608 180821 T1044 H G A V E L P T P L L L P R N
Chicken Gallus gallus XP_421203 1656 188583 T1091 H G A I K L H T P L L M P R N
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_002667149 1483 168725 P973 L F S Q N I S P V T D Y T Y D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001120977 1130 130476 R620 N N V P H I R R Y A I E R V F
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785160 1605 181469 P1092 L F A V E S R P V A D F T Y D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LX30 1241 140303 P731 E L L K H A F P P R M E S E L
Baker's Yeast Sacchar. cerevisiae P15442 1659 190175 I1065 E N N A P P R I F P K A P I Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 N.A. 89.7 N.A. 90.5 N.A. N.A. 74.7 72.3 N.A. 52.6 N.A. N.A. 27.9 N.A. 40.4
Protein Similarity: 100 99.9 N.A. 94.3 N.A. 94.9 N.A. N.A. 84.4 84.5 N.A. 67.4 N.A. N.A. 44 N.A. 59.4
P-Site Identity: 100 100 N.A. 13.3 N.A. 100 N.A. N.A. 86.6 73.3 N.A. 0 N.A. N.A. 0 N.A. 13.3
P-Site Similarity: 100 100 N.A. 13.3 N.A. 100 N.A. N.A. 93.3 93.3 N.A. 20 N.A. N.A. 20 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. 22.5 26.2 N.A.
Protein Similarity: N.A. N.A. N.A. 39.7 46.3 N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 55 10 0 10 0 0 0 19 0 10 0 0 0 % A
% Cys: 0 0 0 0 0 10 28 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 19 0 0 0 19 % D
% Glu: 19 0 0 0 19 0 0 0 0 0 0 19 0 10 0 % E
% Phe: 0 19 0 0 0 0 10 0 10 0 0 10 0 0 10 % F
% Gly: 10 46 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 46 0 0 0 19 0 10 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 10 0 19 0 10 0 0 10 0 0 10 0 % I
% Lys: 0 0 0 10 10 0 0 0 0 0 10 0 0 0 0 % K
% Leu: 19 10 10 0 10 46 0 0 10 55 55 37 0 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 10 10 0 0 0 % M
% Asn: 10 19 10 0 10 0 0 0 0 0 0 0 0 10 46 % N
% Pro: 0 0 0 10 10 10 10 37 55 10 0 10 55 0 0 % P
% Gln: 0 0 0 19 28 0 0 0 0 0 0 0 10 0 0 % Q
% Arg: 0 0 0 0 0 0 28 10 0 10 0 0 10 46 10 % R
% Ser: 0 0 10 0 0 10 10 0 0 0 0 0 10 0 0 % S
% Thr: 0 0 0 0 0 0 10 46 0 10 0 0 19 0 0 % T
% Val: 0 0 19 46 0 0 0 0 19 0 0 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 10 0 0 10 0 19 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _