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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HECW2 All Species: 5.15
Human Site: T766 Identified Species: 9.44
UniProt: Q9P2P5 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9P2P5 NP_065811.1 1572 175769 T766 S A G E A Q G T C E G A T A Q
Chimpanzee Pan troglodytes XP_516001 1572 175733 T766 S A G E A Q G T C E G A T A Q
Rhesus Macaque Macaca mulatta XP_001096775 1606 179529 E788 E R T P E G L E S P V A G P S
Dog Lupus familis XP_850781 1366 151109 R630 A A T P D G M R R S G S I Q Q
Cat Felis silvestris
Mouse Mus musculus Q6I6G8 1578 176216 A772 D A G D A Q G A C E G A T A Q
Rat Rattus norvegicus Q62940 887 102376 N151 L F E V F D E N R L T R D D F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507682 1657 184662 E836 P R T A D G L E S P I A G P S
Chicken Gallus gallus XP_421906 1566 176048 E762 E G A Q A A C E G A T A E V E
Frog Xenopus laevis Q2TAS2 751 86306 R15 R N G P V K L R L T V L C A K
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 F29 K N L V K K D F F R L P D P F
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VVI3 1007 114856 T271 Y V N H T A R T T Q W D R P T
Honey Bee Apis mellifera XP_392900 1204 136801 P467 T P T H R P K P L R P L P L C
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39940 809 91798 Q73 L T I Q V F D Q K K F K K K D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.5 56.7 52.7 N.A. 94.8 25.7 N.A. 53.3 86.7 24.2 23.9 N.A. 27.4 39.6 N.A. N.A.
Protein Similarity: 100 99.6 68.1 62.8 N.A. 96.6 38 N.A. 64.9 91.5 34.5 34.4 N.A. 40 53.4 N.A. N.A.
P-Site Identity: 100 100 6.6 20 N.A. 80 0 N.A. 6.6 13.3 13.3 0 N.A. 6.6 0 N.A. N.A.
P-Site Similarity: 100 100 6.6 33.3 N.A. 86.6 0 N.A. 6.6 26.6 26.6 6.6 N.A. 13.3 6.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 26.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 36.7 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 31 8 8 31 16 0 8 0 8 0 47 0 31 0 % A
% Cys: 0 0 0 0 0 0 8 0 24 0 0 0 8 0 8 % C
% Asp: 8 0 0 8 16 8 16 0 0 0 0 8 16 8 8 % D
% Glu: 16 0 8 16 8 0 8 24 0 24 0 0 8 0 8 % E
% Phe: 0 8 0 0 8 8 0 8 8 0 8 0 0 0 16 % F
% Gly: 0 8 31 0 0 24 24 0 8 0 31 0 16 0 0 % G
% His: 0 0 0 16 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 0 0 0 0 0 0 0 8 0 8 0 0 % I
% Lys: 8 0 0 0 8 16 8 0 8 8 0 8 8 8 8 % K
% Leu: 16 0 8 0 0 0 24 0 16 8 8 16 0 8 0 % L
% Met: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 16 8 0 0 0 0 8 0 0 0 0 0 0 0 % N
% Pro: 8 8 0 24 0 8 0 8 0 16 8 8 8 31 0 % P
% Gln: 0 0 0 16 0 24 0 8 0 8 0 0 0 8 31 % Q
% Arg: 8 16 0 0 8 0 8 16 16 16 0 8 8 0 0 % R
% Ser: 16 0 0 0 0 0 0 0 16 8 0 8 0 0 16 % S
% Thr: 8 8 31 0 8 0 0 24 8 8 16 0 24 0 8 % T
% Val: 0 8 0 16 16 0 0 0 0 0 16 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _