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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
STX18
All Species:
17.58
Human Site:
T181
Identified Species:
29.74
UniProt:
Q9P2W9
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P2W9
NP_058626.1
335
38674
T181
N
T
K
T
R
E
S
T
S
S
E
K
V
S
Q
Chimpanzee
Pan troglodytes
XP_001154387
335
38724
T181
N
T
K
T
R
E
S
T
S
S
E
K
V
S
Q
Rhesus Macaque
Macaca mulatta
XP_001094903
335
38636
T181
N
T
K
T
R
E
S
T
S
S
E
K
V
S
Q
Dog
Lupus familis
XP_851021
336
38679
T182
H
T
K
T
R
E
S
T
S
S
E
K
V
S
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8VDS8
334
38363
S180
P
H
T
K
R
K
D
S
T
S
E
K
A
P
Q
Rat
Rattus norvegicus
Q68FW4
334
38494
P180
P
H
T
K
R
K
E
P
A
S
E
K
S
S
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001089679
372
42507
P180
S
R
S
E
D
S
V
P
L
K
Q
L
D
T
G
Zebra Danio
Brachydanio rerio
Q4VBI7
314
36223
Q179
Q
I
N
T
E
K
R
Q
S
D
G
E
E
N
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524485
395
45117
A241
D
G
E
K
G
K
E
A
N
Q
A
N
Q
H
K
Honey Bee
Apis mellifera
XP_623865
296
34345
K166
E
L
E
K
K
P
I
K
E
F
P
M
K
I
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782212
312
36043
S178
S
K
S
K
Q
S
V
S
N
N
G
D
D
Q
V
Poplar Tree
Populus trichocarpa
XP_002316241
311
35519
K179
K
V
N
R
A
A
N
K
N
T
S
S
V
D
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P59277
310
35555
E179
K
P
K
R
V
I
K
E
A
T
P
I
N
T
T
Baker's Yeast
Sacchar. cerevisiae
P36116
164
18893
P34
F
Y
N
L
E
N
E
P
N
K
G
R
Q
E
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99.6
95.2
N.A.
92.5
92.8
N.A.
N.A.
N.A.
62.6
70.4
N.A.
32.4
46.8
N.A.
48.9
Protein Similarity:
100
99.6
99.6
97.9
N.A.
96.1
96.1
N.A.
N.A.
N.A.
71.5
80.3
N.A.
51.9
66.2
N.A.
64.1
P-Site Identity:
100
100
100
93.3
N.A.
33.3
33.3
N.A.
N.A.
N.A.
0
13.3
N.A.
0
6.6
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
53.3
46.6
N.A.
N.A.
N.A.
20
33.3
N.A.
33.3
20
N.A.
33.3
Percent
Protein Identity:
25
N.A.
N.A.
24.1
20.9
N.A.
Protein Similarity:
46.2
N.A.
N.A.
47.7
32.8
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
26.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
8
0
8
15
0
8
0
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
8
0
8
0
0
8
0
8
15
8
8
% D
% Glu:
8
0
15
8
15
29
22
8
8
0
43
8
8
8
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
8
0
0
8
0
0
0
0
0
22
0
0
0
8
% G
% His:
8
15
0
0
0
0
0
0
0
0
0
0
0
8
8
% H
% Ile:
0
8
0
0
0
8
8
0
0
0
0
8
0
8
0
% I
% Lys:
15
8
36
36
8
29
8
15
0
15
0
43
8
0
8
% K
% Leu:
0
8
0
8
0
0
0
0
8
0
0
8
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
22
0
22
0
0
8
8
0
29
8
0
8
8
8
0
% N
% Pro:
15
8
0
0
0
8
0
22
0
0
15
0
0
8
0
% P
% Gln:
8
0
0
0
8
0
0
8
0
8
8
0
15
8
43
% Q
% Arg:
0
8
0
15
43
0
8
0
0
0
0
8
0
0
0
% R
% Ser:
15
0
15
0
0
15
29
15
36
43
8
8
8
36
8
% S
% Thr:
0
29
15
36
0
0
0
29
8
15
0
0
0
15
8
% T
% Val:
0
8
0
0
8
0
15
0
0
0
0
0
36
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _