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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DNMT3B
All Species:
9.09
Human Site:
T105
Identified Species:
25
UniProt:
Q9UBC3
Number Species:
8
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UBC3
NP_008823.1
853
95751
T105
S
E
S
P
A
V
R
T
R
N
N
N
S
V
S
Chimpanzee
Pan troglodytes
XP_514580
1046
115564
T298
S
E
S
P
A
V
R
T
R
N
N
N
S
V
S
Rhesus Macaque
Macaca mulatta
XP_001107376
854
95742
T105
S
E
S
P
A
V
R
T
R
N
N
N
S
V
S
Dog
Lupus familis
XP_540110
969
107941
E180
A
E
G
E
G
A
A
E
T
P
P
E
A
S
R
Cat
Felis silvestris
Mouse
Mus musculus
O88509
859
97209
R105
I
L
M
P
K
L
T
R
E
T
K
D
T
R
T
Rat
Rattus norvegicus
Q1LZ53
908
101650
E119
P
A
E
G
E
G
T
E
T
P
P
E
A
S
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519246
640
72217
Chicken
Gallus gallus
Q4W5Z4
877
98926
M129
N
N
F
D
S
L
K
M
E
G
S
R
G
R
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001020621
816
91514
D105
T
E
E
D
S
A
W
D
S
S
Y
S
E
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.4
95.7
47.4
N.A.
83.2
47.7
N.A.
59.9
48.6
N.A.
54.8
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
81.5
96.3
59.8
N.A.
89.8
62.2
N.A.
66.9
63.5
N.A.
67.7
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
6.6
0
N.A.
0
0
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
20
N.A.
33.3
6.6
N.A.
0
33.3
N.A.
33.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
12
0
0
34
23
12
0
0
0
0
0
23
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
23
0
0
0
12
0
0
0
12
0
0
0
% D
% Glu:
0
56
23
12
12
0
0
23
23
0
0
23
12
12
0
% E
% Phe:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
12
12
12
12
0
0
0
12
0
0
12
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
12
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
12
0
12
0
0
0
12
0
0
0
12
% K
% Leu:
0
12
0
0
0
23
0
0
0
0
0
0
0
0
12
% L
% Met:
0
0
12
0
0
0
0
12
0
0
0
0
0
0
0
% M
% Asn:
12
12
0
0
0
0
0
0
0
34
34
34
0
0
0
% N
% Pro:
12
0
0
45
0
0
0
0
0
23
23
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
34
12
34
0
0
12
0
23
23
% R
% Ser:
34
0
34
0
23
0
0
0
12
12
12
12
34
23
34
% S
% Thr:
12
0
0
0
0
0
23
34
23
12
0
0
12
0
12
% T
% Val:
0
0
0
0
0
34
0
0
0
0
0
0
0
34
0
% V
% Trp:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _