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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTRR All Species: 7.88
Human Site: S183 Identified Species: 13.33
UniProt: Q9UBK8 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBK8 NP_002445.2 725 80410 S183 A L R K H F R S S R G Q E E I
Chimpanzee Pan troglodytes XP_001145250 725 80375 S183 A L R K H F R S S R G Q E E I
Rhesus Macaque Macaca mulatta XP_001109664 680 76966 D165 W L Q E T D V D L S G V K F A
Dog Lupus familis XP_535797 697 77934 M155 A A L T K H F M S S R E K E R
Cat Felis silvestris
Mouse Mus musculus P37040 678 77025 D162 W L Q E T D V D L T G V K F A
Rat Rattus norvegicus P00388 678 76944 L163 L Q E T D V D L T G V K F A V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519075 915 101962 F377 W T A L Q E Q F T L R K E D M
Chicken Gallus gallus Q90703 1136 129631 R613 L L T L K L L R K N I R Y A V
Frog Xenopus laevis Q6NRG5 600 68059 G120 H K R L N Q L G A C P L L P A
Zebra Danio Brachydanio rerio Q6PFP6 595 66871 R115 V A K K L H K R L L Q L G A N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17574 682 76816 T165 A D K M N A I T E S S N L K L
Sea Urchin Strong. purpuratus XP_787027 728 80257 S219 Q P K T G E Q S S T G N N T S
Poplar Tree Populus trichocarpa XP_002307336 692 76707 Q175 E R G I W L Q Q L S Y G V F G
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_194183 692 76747 Q175 N E R D I K L Q Q L A Y G V F
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.4 27.3 80.6 N.A. 28.1 27.8 N.A. 56 21.2 28 28.5 N.A. N.A. N.A. 31.5 42.9
Protein Similarity: 100 99.1 44.8 87 N.A. 45 44.5 N.A. 65.4 35.9 46.2 44.5 N.A. N.A. N.A. 48.4 60.5
P-Site Identity: 100 100 13.3 20 N.A. 13.3 0 N.A. 6.6 6.6 6.6 6.6 N.A. N.A. N.A. 6.6 20
P-Site Similarity: 100 100 33.3 33.3 N.A. 33.3 20 N.A. 40 20 20 20 N.A. N.A. N.A. 40 33.3
Percent
Protein Identity: 28.1 N.A. N.A. 24.8 N.A. N.A.
Protein Similarity: 47 N.A. N.A. 44.1 N.A. N.A.
P-Site Identity: 0 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 6.6 N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 29 15 8 0 0 8 0 0 8 0 8 0 0 22 22 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % C
% Asp: 0 8 0 8 8 15 8 15 0 0 0 0 0 8 0 % D
% Glu: 8 8 8 15 0 15 0 0 8 0 0 8 22 22 0 % E
% Phe: 0 0 0 0 0 15 8 8 0 0 0 0 8 22 8 % F
% Gly: 0 0 8 0 8 0 0 8 0 8 36 8 15 0 8 % G
% His: 8 0 0 0 15 15 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 8 0 8 0 0 0 8 0 0 0 15 % I
% Lys: 0 8 22 22 15 8 8 0 8 0 0 15 22 8 0 % K
% Leu: 15 36 8 22 8 15 22 8 29 22 0 15 15 0 8 % L
% Met: 0 0 0 8 0 0 0 8 0 0 0 0 0 0 8 % M
% Asn: 8 0 0 0 15 0 0 0 0 8 0 15 8 0 8 % N
% Pro: 0 8 0 0 0 0 0 0 0 0 8 0 0 8 0 % P
% Gln: 8 8 15 0 8 8 22 15 8 0 8 15 0 0 0 % Q
% Arg: 0 8 29 0 0 0 15 15 0 15 15 8 0 0 8 % R
% Ser: 0 0 0 0 0 0 0 22 29 29 8 0 0 0 8 % S
% Thr: 0 8 8 22 15 0 0 8 15 15 0 0 0 8 0 % T
% Val: 8 0 0 0 0 8 15 0 0 0 8 15 8 8 15 % V
% Trp: 22 0 0 0 8 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 8 8 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _