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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTRR All Species: 10.3
Human Site: S341 Identified Species: 17.44
UniProt: Q9UBK8 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBK8 NP_002445.2 725 80410 S341 Y Q P G D A F S V I C P N S D
Chimpanzee Pan troglodytes XP_001145250 725 80375 S341 Y Q P G D A F S V I C P N S D
Rhesus Macaque Macaca mulatta XP_001109664 680 76966 V323 R Y E S G D H V A V Y P A N D
Dog Lupus familis XP_535797 697 77934 N313 Y Q P G D A F N V I C P N S D
Cat Felis silvestris
Mouse Mus musculus P37040 678 77025 V320 R Y E S G D H V A V Y P A N D
Rat Rattus norvegicus P00388 678 76944 A321 Y E S G D H V A V Y P A N D S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519075 915 101962 N535 Y Q P G D S F N V I C P N S D
Chicken Gallus gallus Q90703 1136 129631 G771 Y L P G E H I G I S P G N Q P
Frog Xenopus laevis Q6NRG5 600 68059 V278 H L D P L N K V V V E P S D P
Zebra Danio Brachydanio rerio Q6PFP6 595 66871 T273 L D P E S Y F T L T P T D S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17574 682 76816 N323 A I Y F C V P N P A L E V N F
Sea Urchin Strong. purpuratus XP_787027 728 80257 S377 F Q P G D S F S I I C P N D A
Poplar Tree Populus trichocarpa XP_002307336 692 76707 G333 Y E T G D H L G V Y A E N S D
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_194183 692 76747 G333 Y E T G D H V G V Y A E N H V
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.4 27.3 80.6 N.A. 28.1 27.8 N.A. 56 21.2 28 28.5 N.A. N.A. N.A. 31.5 42.9
Protein Similarity: 100 99.1 44.8 87 N.A. 45 44.5 N.A. 65.4 35.9 46.2 44.5 N.A. N.A. N.A. 48.4 60.5
P-Site Identity: 100 100 13.3 93.3 N.A. 13.3 33.3 N.A. 86.6 26.6 13.3 20 N.A. N.A. N.A. 0 66.6
P-Site Similarity: 100 100 26.6 100 N.A. 26.6 46.6 N.A. 100 40 33.3 40 N.A. N.A. N.A. 13.3 86.6
Percent
Protein Identity: 28.1 N.A. N.A. 24.8 N.A. N.A.
Protein Similarity: 47 N.A. N.A. 44.1 N.A. N.A.
P-Site Identity: 46.6 N.A. N.A. 33.3 N.A. N.A.
P-Site Similarity: 53.3 N.A. N.A. 40 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 22 0 8 15 8 15 8 15 0 8 % A
% Cys: 0 0 0 0 8 0 0 0 0 0 36 0 0 0 0 % C
% Asp: 0 8 8 0 58 15 0 0 0 0 0 0 8 22 50 % D
% Glu: 0 22 15 8 8 0 0 0 0 0 8 22 0 0 0 % E
% Phe: 8 0 0 8 0 0 43 0 0 0 0 0 0 0 8 % F
% Gly: 0 0 0 65 15 0 0 22 0 0 0 8 0 0 0 % G
% His: 8 0 0 0 0 29 15 0 0 0 0 0 0 8 0 % H
% Ile: 0 8 0 0 0 0 8 0 15 36 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % K
% Leu: 8 15 0 0 8 0 8 0 8 0 8 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 8 0 22 0 0 0 0 65 22 0 % N
% Pro: 0 0 50 8 0 0 8 0 8 0 22 58 0 0 15 % P
% Gln: 0 36 0 0 0 0 0 0 0 0 0 0 0 8 0 % Q
% Arg: 15 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 8 15 8 15 0 22 0 8 0 0 8 43 15 % S
% Thr: 0 0 15 0 0 0 0 8 0 8 0 8 0 0 0 % T
% Val: 0 0 0 0 0 8 15 22 58 22 0 0 8 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 58 15 8 0 0 8 0 0 0 22 15 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _