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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTRR All Species: 11.52
Human Site: S535 Identified Species: 19.49
UniProt: Q9UBK8 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBK8 NP_002445.2 725 80410 S535 L Q P N I H A S H E D S G K A
Chimpanzee Pan troglodytes XP_001145250 725 80375 S535 L Q P N I H S S H E D S G K A
Rhesus Macaque Macaca mulatta XP_001109664 680 76966 Q520 P M F V R K S Q F R L P F K A
Dog Lupus familis XP_535797 697 77934 S507 L H P N T R V S P A E D G K A
Cat Felis silvestris
Mouse Mus musculus P37040 678 77025 V509 E N G R R A L V P M F V R K S
Rat Rattus norvegicus P00388 678 76944 V509 E N G G R A L V P M F V R K S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519075 915 101962 R725 L Q P Y G S A R R E G D E Q S
Chicken Gallus gallus Q90703 1136 129631 S960 T V P C F V R S A D G F R L P
Frog Xenopus laevis Q6NRG5 600 68059 P452 S M K F P C D P D T P V V M V
Zebra Danio Brachydanio rerio Q6PFP6 595 66871 P447 S L K F P Q D P E S P V I M V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17574 682 76816 E509 K V Q V L G K E P A R F R L P
Sea Urchin Strong. purpuratus XP_787027 728 80257 T571 R G Q N S Y Q T I M Q N L E E
Poplar Tree Populus trichocarpa XP_002307336 692 76707 S523 L E K S Y E C S W A P I F T R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_194183 692 76747 S523 A E K S H E C S G A P I F I R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.4 27.3 80.6 N.A. 28.1 27.8 N.A. 56 21.2 28 28.5 N.A. N.A. N.A. 31.5 42.9
Protein Similarity: 100 99.1 44.8 87 N.A. 45 44.5 N.A. 65.4 35.9 46.2 44.5 N.A. N.A. N.A. 48.4 60.5
P-Site Identity: 100 93.3 13.3 46.6 N.A. 6.6 6.6 N.A. 33.3 13.3 0 0 N.A. N.A. N.A. 0 6.6
P-Site Similarity: 100 100 20 53.3 N.A. 13.3 13.3 N.A. 46.6 20 0 0 N.A. N.A. N.A. 6.6 33.3
Percent
Protein Identity: 28.1 N.A. N.A. 24.8 N.A. N.A.
Protein Similarity: 47 N.A. N.A. 44.1 N.A. N.A.
P-Site Identity: 13.3 N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: 26.6 N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 15 15 0 8 29 0 0 0 0 29 % A
% Cys: 0 0 0 8 0 8 15 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 15 0 8 8 15 15 0 0 0 % D
% Glu: 15 15 0 0 0 15 0 8 8 22 8 0 8 8 8 % E
% Phe: 0 0 8 15 8 0 0 0 8 0 15 15 22 0 0 % F
% Gly: 0 8 15 8 8 8 0 0 8 0 15 0 22 0 0 % G
% His: 0 8 0 0 8 15 0 0 15 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 15 0 0 0 8 0 0 15 8 8 0 % I
% Lys: 8 0 29 0 0 8 8 0 0 0 0 0 0 43 0 % K
% Leu: 36 8 0 0 8 0 15 0 0 0 8 0 8 15 0 % L
% Met: 0 15 0 0 0 0 0 0 0 22 0 0 0 15 0 % M
% Asn: 0 15 0 29 0 0 0 0 0 0 0 8 0 0 0 % N
% Pro: 8 0 36 0 15 0 0 15 29 0 29 8 0 0 15 % P
% Gln: 0 22 15 0 0 8 8 8 0 0 8 0 0 8 0 % Q
% Arg: 8 0 0 8 22 8 8 8 8 8 8 0 29 0 15 % R
% Ser: 15 0 0 15 8 8 15 43 0 8 0 15 0 0 22 % S
% Thr: 8 0 0 0 8 0 0 8 0 8 0 0 0 8 0 % T
% Val: 0 15 0 15 0 8 8 15 0 0 0 29 8 0 15 % V
% Trp: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 8 8 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _