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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTRR All Species: 13.64
Human Site: Y276 Identified Species: 23.08
UniProt: Q9UBK8 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBK8 NP_002445.2 725 80410 Y276 I P G L P P E Y L Q V H L Q E
Chimpanzee Pan troglodytes XP_001145250 725 80375 Y276 I P A L P P E Y L Q V Y L Q E
Rhesus Macaque Macaca mulatta XP_001109664 680 76966 A258 V V H T D I D A A K V Y V G E
Dog Lupus familis XP_535797 697 77934 Y248 I P A L P P E Y L Q V H L Q E
Cat Felis silvestris
Mouse Mus musculus P37040 678 77025 T255 V V H E D M D T A K V Y T G E
Rat Rattus norvegicus P00388 678 76944 A256 V H E D M D V A K V Y T G E M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519075 915 101962 Y470 I P A L P P E Y L N V Q F Q D
Chicken Gallus gallus Q90703 1136 129631 H706 D S W N P K K H R I V Y D S Q
Frog Xenopus laevis Q6NRG5 600 68059 F213 P P S E I H P F L A P V L S N
Zebra Danio Brachydanio rerio Q6PFP6 595 66871 P208 P T P L R P F P A P L V F N Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q17574 682 76816 L258 K L P E D T K L E W Q N L C K
Sea Urchin Strong. purpuratus XP_787027 728 80257 H312 F L K V V Y A H N E T I D L E
Poplar Tree Populus trichocarpa XP_002307336 692 76707 P268 Y R L V I H D P S I I S V E D
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_194183 692 76747 P268 Y R V V T H D P R F T T Q K S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.4 27.3 80.6 N.A. 28.1 27.8 N.A. 56 21.2 28 28.5 N.A. N.A. N.A. 31.5 42.9
Protein Similarity: 100 99.1 44.8 87 N.A. 45 44.5 N.A. 65.4 35.9 46.2 44.5 N.A. N.A. N.A. 48.4 60.5
P-Site Identity: 100 86.6 13.3 93.3 N.A. 13.3 0 N.A. 66.6 13.3 20 13.3 N.A. N.A. N.A. 6.6 6.6
P-Site Similarity: 100 93.3 46.6 93.3 N.A. 40 13.3 N.A. 73.3 40 26.6 26.6 N.A. N.A. N.A. 26.6 26.6
Percent
Protein Identity: 28.1 N.A. N.A. 24.8 N.A. N.A.
Protein Similarity: 47 N.A. N.A. 44.1 N.A. N.A.
P-Site Identity: 0 N.A. N.A. 0 N.A. N.A.
P-Site Similarity: 40 N.A. N.A. 20 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 22 0 0 0 8 15 22 8 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 8 0 0 8 22 8 29 0 0 0 0 0 15 0 15 % D
% Glu: 0 0 8 22 0 0 29 0 8 8 0 0 0 15 43 % E
% Phe: 8 0 0 0 0 0 8 8 0 8 0 0 15 0 0 % F
% Gly: 0 0 8 0 0 0 0 0 0 0 0 0 8 15 0 % G
% His: 0 8 15 0 0 22 0 15 0 0 0 15 0 0 0 % H
% Ile: 29 0 0 0 15 8 0 0 0 15 8 8 0 0 0 % I
% Lys: 8 0 8 0 0 8 15 0 8 15 0 0 0 8 8 % K
% Leu: 0 15 8 36 0 0 0 8 36 0 8 0 36 8 0 % L
% Met: 0 0 0 0 8 8 0 0 0 0 0 0 0 0 8 % M
% Asn: 0 0 0 8 0 0 0 0 8 8 0 8 0 8 8 % N
% Pro: 15 36 15 0 36 36 8 22 0 8 8 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 22 8 8 8 29 15 % Q
% Arg: 0 15 0 0 8 0 0 0 15 0 0 0 0 0 0 % R
% Ser: 0 8 8 0 0 0 0 0 8 0 0 8 0 15 8 % S
% Thr: 0 8 0 8 8 8 0 8 0 0 15 15 8 0 0 % T
% Val: 22 15 8 22 8 0 8 0 0 8 50 15 15 0 0 % V
% Trp: 0 0 8 0 0 0 0 0 0 8 0 0 0 0 0 % W
% Tyr: 15 0 0 0 0 8 0 29 0 0 8 29 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _