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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DHCR7 All Species: 19.7
Human Site: T89 Identified Species: 28.89
UniProt: Q9UBM7 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBM7 NP_001157289.1 475 54489 T89 L S D I W A K T P P I T R K A
Chimpanzee Pan troglodytes XP_001174170 475 54471 T89 L S D I W A K T P P I T R K A
Rhesus Macaque Macaca mulatta XP_001099101 464 52208 T89 L S D I W A K T P P I T R K A
Dog Lupus familis XP_540796 475 54376 T89 L S D I W A K T P P V T K K A
Cat Felis silvestris
Mouse Mus musculus O88455 471 53900 T89 W A K T P P V T A K A A Q L Y
Rat Rattus norvegicus Q9Z2Z8 471 54136 T89 W A K T P P V T A K A A Q L Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506255 505 58229 T119 L S D I W A K T P S M S Q K A
Chicken Gallus gallus P23913 637 73480 L144 R N D T S S K L L E Q Q K L K
Frog Xenopus laevis Q7ZXH1 473 54804 L90 I W D K T P A L T W T A V K I
Zebra Danio Brachydanio rerio Q7SXF1 478 55171 A92 L F T I W N R A P S F T W A A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_781710 504 58448 Q118 T L T M L W D Q M P S I T W D
Poplar Tree Populus trichocarpa XP_002316435 434 49833 W69 P R P T A I A W K I I A C Y A
Maize Zea mays NP_001148483 450 51183 W85 P M P T L V A W K I I F G F G
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LDU6 432 49573 W67 P R P T L I A W K I I F C Y G
Baker's Yeast Sacchar. cerevisiae P32462 438 50597 L72 Y Y L G N R E L W T V Y C L W
Red Bread Mold Neurospora crassa P38670 490 54704 G94 S A T L W T L G Y Y A L S L V
Conservation
Percent
Protein Identity: 100 99.5 87.7 89.2 N.A. 88 86.7 N.A. 74.2 28.7 75.5 73 N.A. N.A. N.A. N.A. 52.9
Protein Similarity: 100 99.5 90.3 94.9 N.A. 94.5 93.2 N.A. 85.1 42.3 86.1 83.4 N.A. N.A. N.A. N.A. 69
P-Site Identity: 100 100 100 86.6 N.A. 6.6 6.6 N.A. 73.3 13.3 13.3 40 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 20 20 N.A. 93.3 33.3 20 46.6 N.A. N.A. N.A. N.A. 13.3
Percent
Protein Identity: 34.5 34.3 N.A. 33 29.2 30.8
Protein Similarity: 54.1 55.5 N.A. 53.2 46.5 48.7
P-Site Identity: 13.3 6.6 N.A. 6.6 0 6.6
P-Site Similarity: 13.3 6.6 N.A. 6.6 13.3 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 19 0 0 7 32 25 7 13 0 19 25 0 7 44 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 19 0 0 % C
% Asp: 0 0 44 0 0 0 7 0 0 0 0 0 0 0 7 % D
% Glu: 0 0 0 0 0 0 7 0 0 7 0 0 0 0 0 % E
% Phe: 0 7 0 0 0 0 0 0 0 0 7 13 0 7 0 % F
% Gly: 0 0 0 7 0 0 0 7 0 0 0 0 7 0 13 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 7 0 0 38 0 13 0 0 0 19 38 7 0 0 7 % I
% Lys: 0 0 13 7 0 0 38 0 19 13 0 0 13 38 7 % K
% Leu: 38 7 7 7 19 0 7 19 7 0 0 7 0 32 0 % L
% Met: 0 7 0 7 0 0 0 0 7 0 7 0 0 0 0 % M
% Asn: 0 7 0 0 7 7 0 0 0 0 0 0 0 0 0 % N
% Pro: 19 0 19 0 13 19 0 0 38 32 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 7 0 0 7 7 19 0 0 % Q
% Arg: 7 13 0 0 0 7 7 0 0 0 0 0 19 0 0 % R
% Ser: 7 32 0 0 7 7 0 0 0 13 7 7 7 0 0 % S
% Thr: 7 0 19 38 7 7 0 44 7 7 7 32 7 0 0 % T
% Val: 0 0 0 0 0 7 13 0 0 0 13 0 7 0 7 % V
% Trp: 13 7 0 0 44 7 0 19 7 7 0 0 7 7 7 % W
% Tyr: 7 7 0 0 0 0 0 0 7 7 0 7 0 13 13 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _