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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC6
All Species:
9.09
Human Site:
S412
Identified Species:
16.67
UniProt:
Q9UBN7
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UBN7
NP_006035.2
1215
131419
S412
D
P
C
P
M
L
E
S
P
G
A
P
C
R
S
Chimpanzee
Pan troglodytes
XP_515218
669
71461
Rhesus Macaque
Macaca mulatta
XP_001101619
1229
132810
S426
D
P
C
P
M
L
E
S
P
G
A
P
C
R
S
Dog
Lupus familis
XP_855362
1212
132670
N456
L
S
L
E
G
G
Y
N
L
R
A
L
A
E
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2V5
1149
125685
S411
D
P
C
P
M
L
E
S
C
V
V
P
C
A
S
Rat
Rattus norvegicus
Q569C4
588
63939
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519396
803
87971
M67
S
Q
E
F
L
K
L
M
E
S
T
Q
Q
M
S
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001080486
1286
140963
L407
D
P
C
P
R
L
T
L
P
S
A
P
C
Q
S
Zebra Danio
Brachydanio rerio
XP_693858
858
93375
H122
E
C
F
S
I
L
T
H
M
L
K
G
V
A
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001121726
1019
114505
E283
I
H
R
Y
E
N
G
E
F
W
P
N
L
R
E
Nematode Worm
Caenorhab. elegans
Q20296
955
106730
S219
F
W
P
H
L
P
E
S
D
F
D
H
I
G
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RX28
660
72704
Baker's Yeast
Sacchar. cerevisiae
P53973
706
80051
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.4
97.4
80.6
N.A.
73.9
26.4
N.A.
41.8
N.A.
46.8
38.1
N.A.
N.A.
35.7
33.1
N.A.
Protein Similarity:
100
39
97.9
85.5
N.A.
80.5
35.5
N.A.
51.1
N.A.
62.6
49.8
N.A.
N.A.
53.1
48
N.A.
P-Site Identity:
100
0
100
6.6
N.A.
73.3
0
N.A.
6.6
N.A.
66.6
6.6
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
100
0
100
13.3
N.A.
73.3
0
N.A.
13.3
N.A.
73.3
20
N.A.
N.A.
6.6
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.6
20.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
33.9
33.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
31
0
8
16
0
% A
% Cys:
0
8
31
0
0
0
0
0
8
0
0
0
31
0
0
% C
% Asp:
31
0
0
0
0
0
0
0
8
0
8
0
0
0
0
% D
% Glu:
8
0
8
8
8
0
31
8
8
0
0
0
0
8
8
% E
% Phe:
8
0
8
8
0
0
0
0
8
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
8
8
0
0
16
0
8
0
8
8
% G
% His:
0
8
0
8
0
0
0
8
0
0
0
8
0
0
0
% H
% Ile:
8
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% I
% Lys:
0
0
0
0
0
8
0
0
0
0
8
0
0
0
0
% K
% Leu:
8
0
8
0
16
39
8
8
8
8
0
8
8
0
0
% L
% Met:
0
0
0
0
24
0
0
8
8
0
0
0
0
8
0
% M
% Asn:
0
0
0
0
0
8
0
8
0
0
0
8
0
0
0
% N
% Pro:
0
31
8
31
0
8
0
0
24
0
8
31
0
0
0
% P
% Gln:
0
8
0
0
0
0
0
0
0
0
0
8
8
8
8
% Q
% Arg:
0
0
8
0
8
0
0
0
0
8
0
0
0
24
0
% R
% Ser:
8
8
0
8
0
0
0
31
0
16
0
0
0
0
47
% S
% Thr:
0
0
0
0
0
0
16
0
0
0
8
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
8
8
0
8
0
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _