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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC6
All Species:
0.91
Human Site:
S458
Identified Species:
1.67
UniProt:
Q9UBN7
Number Species:
12
Phosphosite Substitution
Charge Score:
0.42
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UBN7
NP_006035.2
1215
131419
S458
E
E
D
N
V
E
E
S
E
E
E
G
P
W
E
Chimpanzee
Pan troglodytes
XP_515218
669
71461
Rhesus Macaque
Macaca mulatta
XP_001101619
1229
132810
N472
E
E
D
N
V
E
E
N
E
E
E
G
P
W
E
Dog
Lupus familis
XP_855362
1212
132670
E501
F
C
A
L
E
A
L
E
P
F
W
E
V
L
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2V5
1149
125685
E457
E
E
A
V
L
E
E
E
E
E
E
G
G
W
E
Rat
Rattus norvegicus
Q569C4
588
63939
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519396
803
87971
V112
V
L
Q
L
V
D
M
V
M
A
G
E
V
R
N
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001080486
1286
140963
E459
G
P
P
E
G
T
D
E
P
P
L
E
K
F
L
Zebra Danio
Brachydanio rerio
XP_693858
858
93375
S167
P
C
P
H
L
P
S
S
G
A
P
C
E
S
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001121726
1019
114505
L328
L
A
I
F
Q
Q
V
L
L
P
M
A
Y
E
F
Nematode Worm
Caenorhab. elegans
Q20296
955
106730
D264
L
P
L
A
T
Q
F
D
P
H
F
V
I
I
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RX28
660
72704
Baker's Yeast
Sacchar. cerevisiae
P53973
706
80051
D15
K
E
V
L
E
N
P
D
H
D
L
K
R
K
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.4
97.4
80.6
N.A.
73.9
26.4
N.A.
41.8
N.A.
46.8
38.1
N.A.
N.A.
35.7
33.1
N.A.
Protein Similarity:
100
39
97.9
85.5
N.A.
80.5
35.5
N.A.
51.1
N.A.
62.6
49.8
N.A.
N.A.
53.1
48
N.A.
P-Site Identity:
100
0
93.3
0
N.A.
66.6
0
N.A.
6.6
N.A.
0
6.6
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
100
0
100
0
N.A.
73.3
0
N.A.
13.3
N.A.
13.3
20
N.A.
N.A.
6.6
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.6
20.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
33.9
33.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
16
8
0
8
0
0
0
16
0
8
0
0
8
% A
% Cys:
0
16
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
0
16
0
0
8
8
16
0
8
0
0
0
0
0
% D
% Glu:
24
31
0
8
16
24
24
24
24
24
24
24
8
8
24
% E
% Phe:
8
0
0
8
0
0
8
0
0
8
8
0
0
8
8
% F
% Gly:
8
0
0
0
8
0
0
0
8
0
8
24
8
0
0
% G
% His:
0
0
0
8
0
0
0
0
8
8
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
0
0
0
0
8
8
0
% I
% Lys:
8
0
0
0
0
0
0
0
0
0
0
8
8
8
0
% K
% Leu:
16
8
8
24
16
0
8
8
8
0
16
0
0
8
16
% L
% Met:
0
0
0
0
0
0
8
0
8
0
8
0
0
0
0
% M
% Asn:
0
0
0
16
0
8
0
8
0
0
0
0
0
0
8
% N
% Pro:
8
16
16
0
0
8
8
0
24
16
8
0
16
0
0
% P
% Gln:
0
0
8
0
8
16
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% R
% Ser:
0
0
0
0
0
0
8
16
0
0
0
0
0
8
8
% S
% Thr:
0
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% T
% Val:
8
0
8
8
24
0
8
8
0
0
0
8
16
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
24
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _