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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC6
All Species:
5.76
Human Site:
S563
Identified Species:
10.56
UniProt:
Q9UBN7
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UBN7
NP_006035.2
1215
131419
S563
T
R
E
L
H
R
E
S
S
N
F
D
S
I
Y
Chimpanzee
Pan troglodytes
XP_515218
669
71461
L71
H
S
P
E
Y
V
S
L
V
R
E
T
Q
V
L
Rhesus Macaque
Macaca mulatta
XP_001101619
1229
132810
S577
T
R
E
L
H
R
E
S
S
N
F
D
S
I
Y
Dog
Lupus familis
XP_855362
1212
132670
L594
L
A
G
R
C
L
T
L
P
T
R
P
A
T
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2V5
1149
125685
T550
Y
V
E
H
L
R
T
T
E
K
M
K
T
R
D
Rat
Rattus norvegicus
Q569C4
588
63939
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519396
803
87971
D205
W
P
H
L
P
E
S
D
W
R
A
A
G
I
G
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001080486
1286
140963
G564
P
R
D
L
H
R
L
G
D
E
Y
N
S
I
Y
Zebra Danio
Brachydanio rerio
XP_693858
858
93375
L260
R
H
E
E
L
R
L
L
S
R
C
H
R
I
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001121726
1019
114505
E421
L
T
L
P
S
I
R
E
T
D
V
R
P
K
V
Nematode Worm
Caenorhab. elegans
Q20296
955
106730
V357
V
D
S
C
V
S
L
V
S
V
L
R
H
H
W
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RX28
660
72704
L62
V
I
W
E
K
L
Q
L
A
G
V
S
Q
R
C
Baker's Yeast
Sacchar. cerevisiae
P53973
706
80051
L108
G
L
I
N
D
P
T
L
S
G
V
D
D
L
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.4
97.4
80.6
N.A.
73.9
26.4
N.A.
41.8
N.A.
46.8
38.1
N.A.
N.A.
35.7
33.1
N.A.
Protein Similarity:
100
39
97.9
85.5
N.A.
80.5
35.5
N.A.
51.1
N.A.
62.6
49.8
N.A.
N.A.
53.1
48
N.A.
P-Site Identity:
100
0
100
0
N.A.
13.3
0
N.A.
13.3
N.A.
46.6
26.6
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
100
13.3
100
6.6
N.A.
26.6
0
N.A.
13.3
N.A.
66.6
26.6
N.A.
N.A.
13.3
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.6
20.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
33.9
33.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
0
0
0
8
0
8
8
8
0
0
% A
% Cys:
0
0
0
8
8
0
0
0
0
0
8
0
0
0
8
% C
% Asp:
0
8
8
0
8
0
0
8
8
8
0
24
8
0
16
% D
% Glu:
0
0
31
24
0
8
16
8
8
8
8
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
16
0
0
0
0
% F
% Gly:
8
0
8
0
0
0
0
8
0
16
0
0
8
0
16
% G
% His:
8
8
8
8
24
0
0
0
0
0
0
8
8
8
0
% H
% Ile:
0
8
8
0
0
8
0
0
0
0
0
0
0
39
0
% I
% Lys:
0
0
0
0
8
0
0
0
0
8
0
8
0
8
0
% K
% Leu:
16
8
8
31
16
16
24
39
0
0
8
0
0
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
0
0
16
0
8
0
0
0
% N
% Pro:
8
8
8
8
8
8
0
0
8
0
0
8
8
0
8
% P
% Gln:
0
0
0
0
0
0
8
0
0
0
0
0
16
0
0
% Q
% Arg:
8
24
0
8
0
39
8
0
0
24
8
16
8
16
0
% R
% Ser:
0
8
8
0
8
8
16
16
39
0
0
8
24
0
0
% S
% Thr:
16
8
0
0
0
0
24
8
8
8
0
8
8
8
0
% T
% Val:
16
8
0
0
8
8
0
8
8
8
24
0
0
8
8
% V
% Trp:
8
0
8
0
0
0
0
0
8
0
0
0
0
0
8
% W
% Tyr:
8
0
0
0
8
0
0
0
0
0
8
0
0
0
24
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _