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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HDAC6 All Species: 7.88
Human Site: S564 Identified Species: 14.44
UniProt: Q9UBN7 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBN7 NP_006035.2 1215 131419 S564 R E L H R E S S N F D S I Y I
Chimpanzee Pan troglodytes XP_515218 669 71461 V72 S P E Y V S L V R E T Q V L G
Rhesus Macaque Macaca mulatta XP_001101619 1229 132810 S578 R E L H R E S S N F D S I Y I
Dog Lupus familis XP_855362 1212 132670 P595 A G R C L T L P T R P A T D A
Cat Felis silvestris
Mouse Mus musculus Q9Z2V5 1149 125685 E551 V E H L R T T E K M K T R D L
Rat Rattus norvegicus Q569C4 588 63939
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519396 803 87971 W206 P H L P E S D W R A A G I G R
Chicken Gallus gallus
Frog Xenopus laevis NP_001080486 1286 140963 D565 R D L H R L G D E Y N S I Y I
Zebra Danio Brachydanio rerio XP_693858 858 93375 S261 H E E L R L L S R C H R I P A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001121726 1019 114505 T422 T L P S I R E T D V R P K V Y
Nematode Worm Caenorhab. elegans Q20296 955 106730 S358 D S C V S L V S V L R H H W N
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RX28 660 72704 A63 I W E K L Q L A G V S Q R C V
Baker's Yeast Sacchar. cerevisiae P53973 706 80051 S109 L I N D P T L S G V D D L G D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 27.4 97.4 80.6 N.A. 73.9 26.4 N.A. 41.8 N.A. 46.8 38.1 N.A. N.A. 35.7 33.1 N.A.
Protein Similarity: 100 39 97.9 85.5 N.A. 80.5 35.5 N.A. 51.1 N.A. 62.6 49.8 N.A. N.A. 53.1 48 N.A.
P-Site Identity: 100 0 100 0 N.A. 13.3 0 N.A. 13.3 N.A. 53.3 26.6 N.A. N.A. 0 6.6 N.A.
P-Site Similarity: 100 13.3 100 6.6 N.A. 33.3 0 N.A. 13.3 N.A. 73.3 26.6 N.A. N.A. 13.3 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 21.6 20.4 N.A.
Protein Similarity: N.A. N.A. N.A. 33.9 33.5 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 0 0 8 0 8 8 8 0 0 16 % A
% Cys: 0 0 8 8 0 0 0 0 0 8 0 0 0 8 0 % C
% Asp: 8 8 0 8 0 0 8 8 8 0 24 8 0 16 8 % D
% Glu: 0 31 24 0 8 16 8 8 8 8 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 16 0 0 0 0 0 % F
% Gly: 0 8 0 0 0 0 8 0 16 0 0 8 0 16 8 % G
% His: 8 8 8 24 0 0 0 0 0 0 8 8 8 0 0 % H
% Ile: 8 8 0 0 8 0 0 0 0 0 0 0 39 0 24 % I
% Lys: 0 0 0 8 0 0 0 0 8 0 8 0 8 0 0 % K
% Leu: 8 8 31 16 16 24 39 0 0 8 0 0 8 8 8 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 0 16 0 8 0 0 0 8 % N
% Pro: 8 8 8 8 8 0 0 8 0 0 8 8 0 8 0 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 0 16 0 0 0 % Q
% Arg: 24 0 8 0 39 8 0 0 24 8 16 8 16 0 8 % R
% Ser: 8 8 0 8 8 16 16 39 0 0 8 24 0 0 0 % S
% Thr: 8 0 0 0 0 24 8 8 8 0 8 8 8 0 0 % T
% Val: 8 0 0 8 8 0 8 8 8 24 0 0 8 8 8 % V
% Trp: 0 8 0 0 0 0 0 8 0 0 0 0 0 8 0 % W
% Tyr: 0 0 0 8 0 0 0 0 0 8 0 0 0 24 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _