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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC6
All Species:
5.45
Human Site:
S898
Identified Species:
10
UniProt:
Q9UBN7
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UBN7
NP_006035.2
1215
131419
S898
S
T
P
G
Q
T
N
S
E
T
A
V
V
A
L
Chimpanzee
Pan troglodytes
XP_515218
669
71461
G384
R
P
P
P
L
L
P
G
G
P
V
C
K
A
A
Rhesus Macaque
Macaca mulatta
XP_001101619
1229
132810
S912
S
T
P
G
Q
T
K
S
E
T
A
V
V
A
L
Dog
Lupus familis
XP_855362
1212
132670
V907
R
S
L
R
V
M
K
V
E
D
K
E
G
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2V5
1149
125685
K864
T
A
S
P
V
S
A
K
E
M
T
T
P
K
G
Rat
Rattus norvegicus
Q569C4
588
63939
C303
R
I
C
A
V
L
E
C
P
G
V
Y
P
E
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519396
803
87971
N518
R
G
E
G
F
T
L
N
V
P
W
N
G
P
R
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001080486
1286
140963
A943
A
E
T
A
V
Q
F
A
A
P
Q
Y
K
M
S
Zebra Danio
Brachydanio rerio
XP_693858
858
93375
S573
A
H
A
P
F
W
S
S
L
R
V
N
I
H
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001121726
1019
114505
G734
A
C
I
G
D
P
L
G
G
C
F
V
T
P
E
Nematode Worm
Caenorhab. elegans
Q20296
955
106730
R670
E
Y
Q
M
A
F
Q
R
V
I
M
P
I
A
Y
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RX28
660
72704
R375
V
I
Q
A
V
R
K
R
L
C
T
Y
W
P
S
Baker's Yeast
Sacchar. cerevisiae
P53973
706
80051
I421
I
E
M
I
D
K
V
I
R
L
Q
S
K
Y
W
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.4
97.4
80.6
N.A.
73.9
26.4
N.A.
41.8
N.A.
46.8
38.1
N.A.
N.A.
35.7
33.1
N.A.
Protein Similarity:
100
39
97.9
85.5
N.A.
80.5
35.5
N.A.
51.1
N.A.
62.6
49.8
N.A.
N.A.
53.1
48
N.A.
P-Site Identity:
100
13.3
93.3
6.6
N.A.
6.6
0
N.A.
13.3
N.A.
0
6.6
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
100
13.3
93.3
13.3
N.A.
20
0
N.A.
20
N.A.
13.3
26.6
N.A.
N.A.
20
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.6
20.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
33.9
33.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
8
8
24
8
0
8
8
8
0
16
0
0
31
8
% A
% Cys:
0
8
8
0
0
0
0
8
0
16
0
8
0
0
8
% C
% Asp:
0
0
0
0
16
0
0
0
0
8
0
0
0
0
0
% D
% Glu:
8
16
8
0
0
0
8
0
31
0
0
8
0
8
8
% E
% Phe:
0
0
0
0
16
8
8
0
0
0
8
0
0
0
0
% F
% Gly:
0
8
0
31
0
0
0
16
16
8
0
0
16
0
8
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
8
16
8
8
0
0
0
8
0
8
0
0
16
0
0
% I
% Lys:
0
0
0
0
0
8
24
8
0
0
8
0
24
8
0
% K
% Leu:
0
0
8
0
8
16
16
0
16
8
0
0
0
0
16
% L
% Met:
0
0
8
8
0
8
0
0
0
8
8
0
0
8
0
% M
% Asn:
0
0
0
0
0
0
8
8
0
0
0
16
0
0
0
% N
% Pro:
0
8
24
24
0
8
8
0
8
24
0
8
16
31
0
% P
% Gln:
0
0
16
0
16
8
8
0
0
0
16
0
0
0
0
% Q
% Arg:
31
0
0
8
0
8
0
16
8
8
0
0
0
0
8
% R
% Ser:
16
8
8
0
0
8
8
24
0
0
0
8
0
0
31
% S
% Thr:
8
16
8
0
0
24
0
0
0
16
16
8
8
0
0
% T
% Val:
8
0
0
0
39
0
8
8
16
0
24
24
16
0
0
% V
% Trp:
0
0
0
0
0
8
0
0
0
0
8
0
8
0
8
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
24
0
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _