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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC6
All Species:
4.55
Human Site:
S981
Identified Species:
8.33
UniProt:
Q9UBN7
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UBN7
NP_006035.2
1215
131419
S981
A
T
L
G
Q
T
T
S
E
E
A
V
G
G
A
Chimpanzee
Pan troglodytes
XP_515218
669
71461
L467
L
G
K
L
L
Y
L
L
D
G
M
L
D
G
Q
Rhesus Macaque
Macaca mulatta
XP_001101619
1229
132810
S995
A
T
L
G
Q
T
T
S
E
E
A
V
G
G
A
Dog
Lupus familis
XP_855362
1212
132670
Q990
T
G
E
T
T
L
Y
Q
T
I
P
E
A
A
T
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2V5
1149
125685
N947
A
A
P
E
N
F
P
N
Q
T
T
S
V
E
A
Rat
Rattus norvegicus
Q569C4
588
63939
L386
E
T
E
A
W
A
R
L
H
K
S
Q
F
Q
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519396
803
87971
G601
T
G
G
Q
P
A
E
G
P
P
R
E
E
P
G
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001080486
1286
140963
L1026
R
G
L
T
M
E
I
L
G
C
S
E
Q
R
E
Zebra Danio
Brachydanio rerio
XP_693858
858
93375
A656
E
S
V
A
V
G
G
A
R
R
K
V
K
P
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001121726
1019
114505
N817
T
Q
K
Q
Y
W
P
N
L
I
F
N
L
S
L
Nematode Worm
Caenorhab. elegans
Q20296
955
106730
L753
V
L
Q
N
R
S
M
L
R
R
L
R
E
E
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RX28
660
72704
A458
A
K
V
D
V
W
Y
A
S
F
G
S
N
M
W
Baker's Yeast
Sacchar. cerevisiae
P53973
706
80051
I504
S
E
S
N
T
I
I
I
V
V
H
D
T
S
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.4
97.4
80.6
N.A.
73.9
26.4
N.A.
41.8
N.A.
46.8
38.1
N.A.
N.A.
35.7
33.1
N.A.
Protein Similarity:
100
39
97.9
85.5
N.A.
80.5
35.5
N.A.
51.1
N.A.
62.6
49.8
N.A.
N.A.
53.1
48
N.A.
P-Site Identity:
100
6.6
100
0
N.A.
13.3
6.6
N.A.
0
N.A.
6.6
6.6
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
100
20
100
0
N.A.
26.6
20
N.A.
0
N.A.
13.3
26.6
N.A.
N.A.
6.6
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.6
20.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
33.9
33.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
31
8
0
16
0
16
0
16
0
0
16
0
8
8
24
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
8
0
0
8
8
0
16
% D
% Glu:
16
8
16
8
0
8
8
0
16
16
0
24
16
16
8
% E
% Phe:
0
0
0
0
0
8
0
0
0
8
8
0
8
0
0
% F
% Gly:
0
31
8
16
0
8
8
8
8
8
8
0
16
24
8
% G
% His:
0
0
0
0
0
0
0
0
8
0
8
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
16
8
0
16
0
0
0
0
0
% I
% Lys:
0
8
16
0
0
0
0
0
0
8
8
0
8
0
8
% K
% Leu:
8
8
24
8
8
8
8
31
8
0
8
8
8
0
8
% L
% Met:
0
0
0
0
8
0
8
0
0
0
8
0
0
8
0
% M
% Asn:
0
0
0
16
8
0
0
16
0
0
0
8
8
0
8
% N
% Pro:
0
0
8
0
8
0
16
0
8
8
8
0
0
16
0
% P
% Gln:
0
8
8
16
16
0
0
8
8
0
0
8
8
8
8
% Q
% Arg:
8
0
0
0
8
0
8
0
16
16
8
8
0
8
0
% R
% Ser:
8
8
8
0
0
8
0
16
8
0
16
16
0
16
0
% S
% Thr:
24
24
0
16
16
16
16
0
8
8
8
0
8
0
8
% T
% Val:
8
0
16
0
16
0
0
0
8
8
0
24
8
0
0
% V
% Trp:
0
0
0
0
8
16
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
8
8
16
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _