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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HDAC6 All Species: 4.55
Human Site: T527 Identified Species: 8.33
UniProt: Q9UBN7 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9UBN7 NP_006035.2 1215 131419 T527 A G R C L T L T P R P A T E A
Chimpanzee Pan troglodytes XP_515218 669 71461 L35 P E R L T A A L D R L R Q R G
Rhesus Macaque Macaca mulatta XP_001101619 1229 132810 T541 A G R C L T L T P R P A T E A
Dog Lupus familis XP_855362 1212 132670 M558 L V Y D P A M M G H Y N L W D
Cat Felis silvestris
Mouse Mus musculus Q9Z2V5 1149 125685 E514 L R I M C H L E E V G L A A R
Rat Rattus norvegicus Q569C4 588 63939
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519396 803 87971 H169 L I V D W D V H H G Q G T Q R
Chicken Gallus gallus
Frog Xenopus laevis NP_001080486 1286 140963 P528 L E R C S R L P S R L A T Q K
Zebra Danio Brachydanio rerio XP_693858 858 93375 V224 S S P I T G L V Y D Q R M M L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001121726 1019 114505 G385 K V A V I L E G G Y C L K S L
Nematode Worm Caenorhab. elegans Q20296 955 106730 A321 G Y N H Q I S A V A V Q R C V
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8RX28 660 72704 K26 V A G N R Q R K V G L I Y D E
Baker's Yeast Sacchar. cerevisiae P53973 706 80051 I72 R M R Y H A K I F T S Y F E Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 27.4 97.4 80.6 N.A. 73.9 26.4 N.A. 41.8 N.A. 46.8 38.1 N.A. N.A. 35.7 33.1 N.A.
Protein Similarity: 100 39 97.9 85.5 N.A. 80.5 35.5 N.A. 51.1 N.A. 62.6 49.8 N.A. N.A. 53.1 48 N.A.
P-Site Identity: 100 13.3 100 0 N.A. 6.6 0 N.A. 6.6 N.A. 40 6.6 N.A. N.A. 0 0 N.A.
P-Site Similarity: 100 13.3 100 6.6 N.A. 6.6 0 N.A. 20 N.A. 46.6 13.3 N.A. N.A. 6.6 0 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 21.6 20.4 N.A.
Protein Similarity: N.A. N.A. N.A. 33.9 33.5 N.A.
P-Site Identity: N.A. N.A. N.A. 0 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 8 8 0 0 24 8 8 0 8 0 24 8 8 16 % A
% Cys: 0 0 0 24 8 0 0 0 0 0 8 0 0 8 0 % C
% Asp: 0 0 0 16 0 8 0 0 8 8 0 0 0 8 8 % D
% Glu: 0 16 0 0 0 0 8 8 8 0 0 0 0 24 8 % E
% Phe: 0 0 0 0 0 0 0 0 8 0 0 0 8 0 0 % F
% Gly: 8 16 8 0 0 8 0 8 16 16 8 8 0 0 8 % G
% His: 0 0 0 8 8 8 0 8 8 8 0 0 0 0 0 % H
% Ile: 0 8 8 8 8 8 0 8 0 0 0 8 0 0 0 % I
% Lys: 8 0 0 0 0 0 8 8 0 0 0 0 8 0 8 % K
% Leu: 31 0 0 8 16 8 39 8 0 0 24 16 8 0 16 % L
% Met: 0 8 0 8 0 0 8 8 0 0 0 0 8 8 0 % M
% Asn: 0 0 8 8 0 0 0 0 0 0 0 8 0 0 0 % N
% Pro: 8 0 8 0 8 0 0 8 16 0 16 0 0 0 0 % P
% Gln: 0 0 0 0 8 8 0 0 0 0 16 8 8 16 0 % Q
% Arg: 8 8 39 0 8 8 8 0 0 31 0 16 8 8 16 % R
% Ser: 8 8 0 0 8 0 8 0 8 0 8 0 0 8 0 % S
% Thr: 0 0 0 0 16 16 0 16 0 8 0 0 31 0 0 % T
% Val: 8 16 8 8 0 0 8 8 16 8 8 0 0 0 8 % V
% Trp: 0 0 0 0 8 0 0 0 0 0 0 0 0 8 0 % W
% Tyr: 0 8 8 8 0 0 0 0 8 8 8 8 8 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _