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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC6
All Species:
8.18
Human Site:
T551
Identified Species:
15
UniProt:
Q9UBN7
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UBN7
NP_006035.2
1215
131419
T551
Y
V
G
H
L
R
A
T
E
K
M
K
T
R
E
Chimpanzee
Pan troglodytes
XP_515218
669
71461
E59
A
R
E
A
S
E
E
E
L
G
L
V
H
S
P
Rhesus Macaque
Macaca mulatta
XP_001101619
1229
132810
T565
Y
V
G
H
L
R
A
T
E
K
M
K
T
R
E
Dog
Lupus familis
XP_855362
1212
132670
L582
V
F
R
I
M
R
R
L
E
E
L
G
L
A
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2V5
1149
125685
C538
L
G
S
E
L
L
T
C
H
S
A
E
Y
V
E
Rat
Rattus norvegicus
Q569C4
588
63939
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519396
803
87971
E193
Y
F
S
I
H
R
Y
E
H
A
R
F
W
P
H
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001080486
1286
140963
S552
Y
I
Q
K
I
E
A
S
A
H
M
K
P
R
D
Zebra Danio
Brachydanio rerio
XP_693858
858
93375
S248
P
E
L
P
Q
R
I
S
R
I
F
S
R
H
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001121726
1019
114505
P409
T
L
L
S
D
P
C
P
M
L
E
T
L
T
L
Nematode Worm
Caenorhab. elegans
Q20296
955
106730
P345
S
I
E
L
N
E
A
P
K
E
S
T
V
D
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RX28
660
72704
P50
G
E
D
H
P
E
C
P
D
R
I
R
V
I
W
Baker's Yeast
Sacchar. cerevisiae
P53973
706
80051
I96
R
I
Y
R
I
Y
K
I
L
A
E
N
G
L
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.4
97.4
80.6
N.A.
73.9
26.4
N.A.
41.8
N.A.
46.8
38.1
N.A.
N.A.
35.7
33.1
N.A.
Protein Similarity:
100
39
97.9
85.5
N.A.
80.5
35.5
N.A.
51.1
N.A.
62.6
49.8
N.A.
N.A.
53.1
48
N.A.
P-Site Identity:
100
0
100
13.3
N.A.
13.3
0
N.A.
13.3
N.A.
33.3
13.3
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
100
6.6
100
33.3
N.A.
20
0
N.A.
13.3
N.A.
60
20
N.A.
N.A.
6.6
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.6
20.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
33.9
33.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
8
0
0
31
0
8
16
8
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
16
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
8
0
0
0
8
0
0
0
0
8
8
% D
% Glu:
0
16
16
8
0
31
8
16
24
16
16
8
0
0
31
% E
% Phe:
0
16
0
0
0
0
0
0
0
0
8
8
0
0
0
% F
% Gly:
8
8
16
0
0
0
0
0
0
8
0
8
8
0
8
% G
% His:
0
0
0
24
8
0
0
0
16
8
0
0
8
8
8
% H
% Ile:
0
24
0
16
16
0
8
8
0
8
8
0
0
8
8
% I
% Lys:
0
0
0
8
0
0
8
0
8
16
0
24
0
0
0
% K
% Leu:
8
8
16
8
24
8
0
8
16
8
16
0
16
8
8
% L
% Met:
0
0
0
0
8
0
0
0
8
0
24
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
0
0
0
8
0
0
0
% N
% Pro:
8
0
0
8
8
8
0
24
0
0
0
0
8
8
8
% P
% Gln:
0
0
8
0
8
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
8
8
8
0
39
8
0
8
8
8
8
8
24
0
% R
% Ser:
8
0
16
8
8
0
0
16
0
8
8
8
0
8
8
% S
% Thr:
8
0
0
0
0
0
8
16
0
0
0
16
16
8
0
% T
% Val:
8
16
0
0
0
0
0
0
0
0
0
8
16
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% W
% Tyr:
31
0
8
0
0
8
8
0
0
0
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _