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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HDAC6
All Species:
5.45
Human Site:
T868
Identified Species:
10
UniProt:
Q9UBN7
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9UBN7
NP_006035.2
1215
131419
T868
P
R
L
A
E
R
M
T
T
R
E
K
K
V
L
Chimpanzee
Pan troglodytes
XP_515218
669
71461
W354
R
A
A
Q
A
P
H
W
K
S
L
Q
Q
Q
D
Rhesus Macaque
Macaca mulatta
XP_001101619
1229
132810
T882
P
R
L
A
E
R
M
T
T
R
E
K
K
V
L
Dog
Lupus familis
XP_855362
1212
132670
S877
P
P
P
L
L
T
L
S
R
P
P
L
S
G
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2V5
1149
125685
R834
R
K
Y
W
R
S
L
R
L
S
K
M
E
D
K
Rat
Rattus norvegicus
Q569C4
588
63939
G273
S
A
I
G
D
P
E
G
Q
M
Q
A
T
P
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519396
803
87971
H488
S
V
L
Y
V
S
L
H
R
Y
D
H
G
S
F
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001080486
1286
140963
E913
L
S
S
V
S
I
E
E
T
P
I
P
L
I
P
Zebra Danio
Brachydanio rerio
XP_693858
858
93375
P543
S
M
L
L
G
D
S
P
P
S
L
D
H
L
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001121726
1019
114505
Q704
A
E
Y
I
A
A
F
Q
Q
I
I
M
P
I
A
Nematode Worm
Caenorhab. elegans
Q20296
955
106730
V640
E
P
K
D
Y
S
D
V
G
E
G
A
G
E
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8RX28
660
72704
Q345
K
S
S
L
A
C
V
Q
V
L
L
E
D
K
Q
Baker's Yeast
Sacchar. cerevisiae
P53973
706
80051
A391
A
R
S
A
L
S
V
A
K
V
L
I
G
E
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.4
97.4
80.6
N.A.
73.9
26.4
N.A.
41.8
N.A.
46.8
38.1
N.A.
N.A.
35.7
33.1
N.A.
Protein Similarity:
100
39
97.9
85.5
N.A.
80.5
35.5
N.A.
51.1
N.A.
62.6
49.8
N.A.
N.A.
53.1
48
N.A.
P-Site Identity:
100
0
100
6.6
N.A.
0
0
N.A.
6.6
N.A.
6.6
6.6
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
100
13.3
100
20
N.A.
26.6
20
N.A.
20
N.A.
13.3
13.3
N.A.
N.A.
6.6
0
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.6
20.4
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
33.9
33.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
16
8
24
24
8
0
8
0
0
0
16
0
0
16
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
8
8
8
0
0
0
8
8
8
8
8
% D
% Glu:
8
8
0
0
16
0
16
8
0
8
16
8
8
16
8
% E
% Phe:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
0
8
8
0
0
8
8
0
8
0
24
8
8
% G
% His:
0
0
0
0
0
0
8
8
0
0
0
8
8
0
0
% H
% Ile:
0
0
8
8
0
8
0
0
0
8
16
8
0
16
0
% I
% Lys:
8
8
8
0
0
0
0
0
16
0
8
16
16
8
8
% K
% Leu:
8
0
31
24
16
0
24
0
8
8
31
8
8
8
16
% L
% Met:
0
8
0
0
0
0
16
0
0
8
0
16
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
24
16
8
0
0
16
0
8
8
16
8
8
8
8
16
% P
% Gln:
0
0
0
8
0
0
0
16
16
0
8
8
8
8
8
% Q
% Arg:
16
24
0
0
8
16
0
8
16
16
0
0
0
0
0
% R
% Ser:
24
16
24
0
8
31
8
8
0
24
0
0
8
8
0
% S
% Thr:
0
0
0
0
0
8
0
16
24
0
0
0
8
0
8
% T
% Val:
0
8
0
8
8
0
16
8
8
8
0
0
0
16
0
% V
% Trp:
0
0
0
8
0
0
0
8
0
0
0
0
0
0
0
% W
% Tyr:
0
0
16
8
8
0
0
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _